細胞表面受體TLR5可識別鞭毛蛋白，后者是革蘭氏陽性菌和革蘭氏陰性菌表面鞭毛絲的主要成份。TLR5活化后通過MyD88信號通路促進一些炎癥因子的釋放。TLR5通過形成同源二聚體來激活炎癥信號通路，這顯示它可能是唯一參與鞭毛蛋白識別的TLR分子。
TLR5激動劑產(chǎn)品如下：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
TLR5 Agonists |
FLA-BS | Standard flagellin from?B. subtilis?- 10% pure | TLR2 + /TLR4 + | 10 ng - 10?μg/ml | 100?μg | tlrl-bsfla |
FLA-BS Ultrapure | Ultrapure flagellin from?B. subtilis?- >95% pure | TLR2 - /TLR4 - | 1 ng - 1?μg/ml | 50?μg | tlrl-pbsfla |
FLA-PA Ultrapure | Ultrapure flagellin from?P. aeruginosa?- >95% pure | TLR2 - /TLR4 - | 1 ng - 1?μg/ml | 50?μg | tlrl-pafla |
FLA-ST | Standard flagellin from?S. typhimurium?- 10% pure | TLR2 + /TLR4 + | 10 ng - 10?μg/ml | 100?μg | tlrl-stfla |
FLA-ST Ultrapure | Ultrapure flagellin from?S. typhimurium?- >95% pure | TLR2 - /TLR4 - | 10 - 100 ng/ml | 10?μg 50?μg | tlrl-epstfla tlrl-epstfla-5 |
RecFLA-ST | Recombinant flagellin from?S. typhimurium | TLR2 - /TLR4 - | 10 - 100 ng/ml | 50?μg 10?μg | tlrl-flic-50 tlrl-flic-10 |
Flagellin Flic VacciGrade? | Preclinical grade RecFLA-ST | VacciGrade? | 1 - 10?μg/mouse | 50?μg | vac-fla |
TLR5 Antagonist |
hTLR5-Fc | Soluble ectodomain of TLR5 | TLR2 - /TLR4 - | 10 ng- 1?μg/ml | 50?μg | fc-htlr5 |
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