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細(xì)胞因子報告基因細(xì)胞/趨勢因子測試細(xì)胞

2023-02-28
瀏覽次數(shù): 56

細(xì)胞因子與免疫系統(tǒng)細(xì)胞相互作用可調(diào)節(jié)宿主對于疾病和感染的反應(yīng),并介導(dǎo)正常的細(xì)胞過程。InvivoGen提供針對不同細(xì)胞因子(干擾素、白細(xì)胞介素、TNF和TGF)信號通路的報告基因細(xì)胞。所有細(xì)胞系的生物活性均經(jīng)過嚴(yán)格的功能測試分析。另外,InvivoGen也提供一系列細(xì)胞因子報告基因細(xì)胞,可用于研究在更多嚴(yán)重感染病例中,如SARS-CoV-2引發(fā)的高度炎癥反應(yīng)的通路。


細(xì)胞系產(chǎn)品名稱表達(dá)系統(tǒng)報告系統(tǒng)貨號
INTERFERONREPORTERCELLS
B16(mouse)B16-Blue?IFN-α/βMousetypeIIFNs(JAK/ISGF3pathway)SEAPbb-ifnt1
B16-Blue?IFN-γMousetypeIIIFN(JAK/STAT-1pathway)SEAPbb-ifng
HEK293(human)HEK-Blue?IFN-α/βHumantypeIIFNs(JAK/ISGF3pathway)SEAPhkb-ifnab
HEK-Blue?IFN-γHumantypeIIIFN(JAK/STAT-1pathway)SEAPhkb-ifng
HEK-Blue?IFN-λHumantypeIIIIFN(JAK/ISGF3pathway)SEAPhkb-ifnl
HEK-Dual?IFN-γHumantypeIIIFN(JAK/STAT-1pathway)SEAP/Luciahkd-ifng
INTERLEUKINREPORTERCELLS
HEK293?(human)HEK-Blue?IL-1βHuman&mouseIL-1β(NF-κB/AP-1pathway)SEAPhkb-il1b
HEK-Blue?IL-1RHuman&mouseIL-1α/β(NF-κB/AP-1pathway)SEAPhkb-il1r
HEK-Blue?IL-2Human&mouseIL-2(STAT-5pathway)SEAPhkb-il2
HEK-Blue?CD122/CD132HumanIL-2&IL-15(STAT-5pathway)SEAPhkb-il2bg
HEK-Blue?IL-4/IL-13HumanIL-4andhuman&mouseIL-13(STAT-6pathway)SEAPhkb-il413
HEK-Blue?IL-5Human&mouseIL-5(STAT-5pathway)SEAPhkb-il5
HEK-Blue?IL-6HumanIL-6(STAT-3pathway)SEAPhkb-hil6
HEK-Blue?IL-7Human&mouseIL-7(STAT-5pathway)SEAPhkb-il7
HEK-Blue?IL-9Human&mouseIL-9(STAT-5pathway)SEAPhkb-il9
HEK-Blue?IL-10HumanIL-10(STAT-3pathway)SEAPhkb-hil10
HEK-Blue?IL-11Human&mouseIL-11(STAT-3pathway)SEAPhkb-il11
HEK-Blue?IL-12Human&mouseIL-12(STAT-4pathway)SEAPhkb-il12
HEK-Blue?IL-17HumanIL-17A/Fandhuman&mouseIL-17E(NF-κB/AP-1pathway)SEAPhkb-il17
HEK-Blue?IL-17CHuman&mouseIL-17C/EandhumanIL-17A(NF-κB/AP-1pathway)SEAPhkb-il17c
HEK-Blue?IL-18Human&mouseIL-18(NF-κB/AP-1pathway)SEAPhkb-hmil18
HEK-Blue?IL-22Human&mouseIL-22(STAT-3pathway)SEAPhkb-hmil22
HEK-Blue?IL-23Human&mouseIL-23(STAT-3pathway)SEAPhkb-hmil23
HEK-Blue?IL-33HumanIL-33reportercells(NF-κB/AP-1pathway)SEAPhkb-hil33
HEK-Blue?IL-36HumanIL-36reportercells(NF-κB/AP-1pathway)SEAPhkb-hil36
TUMORNECROSISFACTORFAMILYCYTOKINES&TUMORGROWTHFACTORREPORTERCELLS
HEK293?(human)HEK-Blue?CD40LHumanCD40L(NF-κBpathway)SEAPhkb-cd40
HEK-Blue?RANKLHuman&mouseRANKL(NF-κB/AP-1pathway)SEAPhkb-rankl
HEK-Blue?TNF-αHuman&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88SEAPhkb-tnfdmyd
HEK-Dual?TNF-αHuman&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88SEAP/Luciahkd-tnfa
HEK-Blue?TGF-βHumanTGF-β(TGFBRI/Smad3/4pathway)SEAPhkb-tgfb
HEK-Blue?TPOHuman&mouseTPO(STAT5pathway)

CHEMOKINETESTCELLS
THP-1(human)THP1-Blue?KI-IP10LuciaknockedintohumanIP10(CXCL10)(parentalcelllineTHP1-Blue?NF-κB)SEAP/Luciathpb-ip10kilc


使用INVIVOGEN細(xì)胞因子效應(yīng)器細(xì)胞的優(yōu)點


  1. 細(xì)胞因子生物活性的檢測 ?

  2. 高靈敏度

  3. 成本效益 ?

  4. 廣泛的動態(tài)范圍

  5. 短暫動手實驗

  6. 裸眼視覺化

  7. 適用于藥物篩選(普通篩選或高通量篩選,動力學(xué))



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