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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CSF1R (CD115)

2023-09-01
瀏覽次數(shù): 251

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CSF1R (CD115)

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產(chǎn)品描述:

AFS98-CP131單克隆抗體是原始AFS98單克隆抗體的重組嵌合型抗體。可變結(jié)構(gòu)域序列與原始AFS98單克隆抗體相同,但是恒定區(qū)序列已經(jīng)從大鼠IgG2a變到小鼠IgG2a。AFS98-CP131單克隆抗體像原始大鼠IgG2a抗體一樣,不包含F(xiàn)c突變。

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AFS98-CP131單克隆抗體能與小鼠集落刺激因子1受體(CSF1R),也稱為巨噬細胞集落刺激因子受體(M-CSFR),即CD115反應。CSF1R是一種單程I型膜蛋白,是血小板衍生生長因子受體家族的成員。在小鼠中,CSF1R由單核細胞/巨噬細胞、腹膜滲出物細胞、漿細胞樣和常規(guī)樹突細胞以及破骨細胞表達。CSF1R是CSF1的受體,CSF1通過CSF1R調(diào)節(jié)單核細胞譜系中細胞的增殖和分化。據(jù)報道,AFS98單克隆抗體可在體內(nèi)deplete巨噬細胞并阻斷CSFR1。

BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CSF1R (CD115)

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產(chǎn)品詳情:

產(chǎn)品名稱

RecombiMAb anti-mouse CSF1R (CD115)

產(chǎn)品貨號

CP131

產(chǎn)品規(guī)格

1/5/25/50/100mg

反應種屬

Mouse

克隆號

AFS98-CP131

同種型

Mouse IgG2a(switched from rat IgG2a)

免疫原

Not available or unknown

實驗應用

in vivo?macrophage depletion*
in vitro?CSF1R neutralization*
in vivo?monocyte depletion*
Flow cytometry*
Western blot*
*Reported for the original rat IgG2a AFS98 antibody

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無菌處理

0.2 μm filtration

純化方式

Protein A

分子量

150 kDa

小鼠病原檢測

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C,不能冷凍保存。

推薦同型對照

InVivoPlus mouse IgG2a isotype control, unknown specificity(貨號BP0085)

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer(貨號IP0070)

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該產(chǎn)品自上市已被多篇SCI文獻引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻引用:

應用

文章

體內(nèi)巨噬細胞耗竭

(in vivo macrophage?

depletion)

1.?Bauche, D., et al. (2018). 'LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing?

CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis'?

Immunity 49(2): 342-352 e345.

2.?Gordon, S. R., et al. (2017). 'PD-1 expression by tumour-associated macrophages inhibits?

phagocytosis and tumour immunity' Nature 545(7655): 495-499.

3.?Moynihan, K. D., et al. (2016). 'Eradication of large established tumors in mice by combination?

immunotherapy that engages innate and adaptive immune responses' Nat Med. doi : 10.1038/nm.4200.

4.?Naik, S., et al. (2015). 'Commensal-dendritic-cell interaction specifies a unique protective?

skin immune signature' Nature 520(7545): 104-108.

體外CSF-R1中和

(in vitro CSF-R1?

neutralization)

1.Sheng, K. C., et al. (2014). 'IL-3 and CSF-1 interact to promote generation of?

CD11c+IL-10-producing macrophages' PLoS One 9(4): e95208.?

流式細胞術(shù)

(Flow Cytometry)

1.?Li, W., et al. (2012). 'Intravital 2-photon imaging of leukocyte trafficking in beating?

heart' J Clin Invest 122(7): 2499-2508.?

2.?Tagliani, E., et al. (2011). 'Coordinate regulation of tissue macrophage and dendritic?

cell population dynamics by CSF-1' J Exp Med 208(9): 1901-1916.

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BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CSF1R (CD115)

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