Heptelidic acid是一種倍半萜類抗生素。Heptelidic acid與甘油醛3-磷酸脫氫酶(GAPDH)催化位點(diǎn)的必需Cys149殘基結(jié)合,是一種特異性 GAPDH 抑制劑。Heptelidic acid通過下調(diào)半胱天冬酶從而抑制Etoposide誘導(dǎo)的細(xì)胞凋亡,它還能減少乳酸分泌,減少總蛋白合成和IFN-α和TNF的產(chǎn)生。
產(chǎn)品詳情
別名:Koningic acid; Avocettin; FO-4443; BRN 5091359; HPA
來源:Isolated from Trichoderma sp.
分子式:C15H20O5
分子量:280.3
CAS號(hào):57710-57-3 (74310-84-2 deleted)
純度:≥95% (HPLC)
該產(chǎn)品自上市以來有多篇文獻(xiàn)引用,品質(zhì)有保證,以下是最新發(fā)表的文獻(xiàn)引用:
1.Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters: K.M. Grzes, et al.; Immunity 54, 2514 (2021)
2.Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control: S. Isozaki, et al.; BMC Microbiol. 22, 110 (2022)
訂購信息:
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