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IL-33 (oxidation resistant) (human) (rec.) (untagged)
品牌： Adipogen
產(chǎn)品貨號(hào)： AG-40B-0160-C100
規(guī)格： 100 ug

報(bào)價(jià)：
折后價(jià)：

數(shù)量： - +
產(chǎn)品詳情
* 以下信息僅供參考，詳情請(qǐng)以原廠網(wǎng)站為準(zhǔn)
  • 產(chǎn)品名稱:
    IL-33 (oxidation resistant) (human) (rec.) (untagged)
  • 別名:
    IL-33 (human) (C208S/C232S Mutant); Interleukin-33 (human) (C208S/C232S Mutant); IL-1F11; NF-HEV
  • 產(chǎn)品描述:
    Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
  • 反應(yīng)種屬:
  • 宿主來(lái)源:
    E. coli
  • 實(shí)驗(yàn)應(yīng)用:
  • 靶標(biāo)/特異性:
  • 同種型:
  • 推薦稀釋度:
  • 免疫原:
  • 免疫原種屬:
  • 克隆性:
  • 克隆號(hào):
  • 純化方式:
  • 偶聯(lián):
  • 產(chǎn)品濃度:
    After reconstitution:for 10μg size: 0.1mg/mlfor 100μg size: 1mg/ml
  • 表達(dá)系統(tǒng):
  • 陽(yáng)性對(duì)照:
  • 保存溫度:
    -20°C
  • 運(yùn)輸溫度:
    BLUE ICE
  • 細(xì)胞定位:
  • 預(yù)期分子量:
    ~17kDa (SDS-PAGE); Monomer (Size Exclusion Chromatography)
  • 產(chǎn)品形式:
    solid
  • 存儲(chǔ)溶液:
    Lyophilized. Contains PBS + 1mM DTT
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 產(chǎn)地:
    瑞士
  • 外觀:
  • 生產(chǎn)商:
  • 功能與背景:
  • URL:
  • 靈敏度:
  • 檢測(cè)范圍:
  • 檢測(cè)方法:
  • 樣本類型:
    Lyophilized. Contains PBS + 1mM DTT
  • 產(chǎn)品特點(diǎn):
  • 純度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 內(nèi)毒素水平:
  • 來(lái)源:
  • 表達(dá)方式:
  • Accession #:
  • CAS號(hào):
  • 分子式:
  • 溶解度:
  • PubChem CID:
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