缺血性心臟病是由于冠狀動脈疾病引起的心肌變性、壞死和纖維化,并導(dǎo)致嚴(yán)重左室功能障礙的一種疾病,是導(dǎo)致心力衰竭常見的原因,通過成功開通閉塞的冠狀動脈治療心肌梗死的可顯著降低死亡率,因此,學(xué)者針對左心室病理性重塑進(jìn)行了大量研究。心室重塑與心臟功能和結(jié)構(gòu)的變化有關(guān),臨床和實(shí)驗(yàn)研究都表明炎癥反應(yīng)參與心肌梗死后心室重塑,清除梗死區(qū)域死亡細(xì)胞和細(xì)胞外基質(zhì)碎片,然而,過度活躍的炎癥信號會加劇心肌損傷并導(dǎo)致不良的心室重塑。近日,華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院心血管內(nèi)科夏霓和程翔教授團(tuán)隊(duì)在期刊《Basic research in cardiology》(IF:?17.165)上發(fā)表了題為“Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration”的文章,旨在確定調(diào)節(jié)性B細(xì)胞(Bregs)對心室重構(gòu)的影響,并探討其相關(guān)機(jī)制。本研究發(fā)現(xiàn)過繼轉(zhuǎn)移Bregs可改善小鼠心肌梗死模型中的心室重構(gòu),如改善心臟功能、減少瘢痕大小和減輕間質(zhì)纖維化,但不改變存活率。從機(jī)制上講,Bregs降低了單核細(xì)胞中C-C基序趨化因子受體2(CCR2)的表達(dá),這抑制了促炎性單核細(xì)胞從外周血向心臟募集和骨髓動員。用白細(xì)胞介素10(IL-10)抗體治療可消除Breg介導(dǎo)的心肌梗死保護(hù)作用。最后,IL-10中和作用改變了Bregs對單核細(xì)胞遷移和CCR2表達(dá)的影響。目前的研究表明,通過減少CCR2介導(dǎo)的單核細(xì)胞募集和動員,Bregs在限制心肌梗死后心室重構(gòu)方面具有治療價值。
本文中使用了欣博盛小鼠IL-10和TGF-β1 ELISA試劑盒,檢測了小鼠脾臟組織中IL-10的表達(dá)量以及小鼠脾臟調(diào)節(jié)性B細(xì)胞和對照B細(xì)胞中IL-10和TGF-β1的表達(dá)情況。
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1.文章題目:Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration.
期 ???刊:Basic research in cardiology(影響因子:17.165)
發(fā)表時間:24 July 2021
作 ???者:Jiao J, He S, Wang Y, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院
使用產(chǎn)品:Mouse IL-10 and TGF-β1 ELISA Kits
樣本類型:脾臟組織(IL-10)
https://pubmed.ncbi.nlm.nih.gov/34302556/
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2.文章題目:TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling.
期 ???刊:Biomaterials(影響因子:12.479)
發(fā)表時間:6 July 2021
作 ???者:Dai L, Li X, Zheng X, et al.
作者單位:西北工業(yè)大學(xué)
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/abs/pii/S0142961221003665
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3.文章題目:Microenvironment Activatable Nanoprodrug Based on Gripper-like Cyclic Phenylboronic Acid to Precisely and Effectively Alleviate Drug-induced Hepatitis.
期 ???刊:Theranostics(影響因子:11.556)
發(fā)表時間:13 July 2021
作 ???者:Zhang Q, Li S, Cai L, et al.
作者單位:電子科技大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA Kits
樣本類型:肝臟組織
https://pubmed.ncbi.nlm.nih.gov/34373743/
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4.文章題目:Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli.
期 ???刊:Journal of Nanobiotechnology(影響因子:10.435)
發(fā)表時間:12 July 2021
作 ???者:Huang X, Huang D, Zhu T, et al.
作者單位:浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TNF-α and IL-10 ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34247649/
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5.文章題目:Oxygen Self-Supplying Nanotherapeutic for Mitigation of Tissue Hypoxia and Enhanced Photodynamic Therapy of Bacterial Keratitis.
期 ???刊:ACS Applied Materials & Interfaces(影響因子:9.229)
發(fā)表時間:13 July 2021
作 ???者:Bai Y, Hu Y, Gao Y, et al.
作者單位:南開大學(xué)
使用產(chǎn)品:Rat?TNF-α, IL-6 and MMP-9?ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34254513/
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6.文章題目:Biomimetic-Coated Nanoplatform with Lipid-Specific Imaging and ROS Responsiveness for Atherosclerosis-Targeted Theranostics.
期 ???刊:ACS Applied Materials & Interfaces(影響因子:9.229)
發(fā)表時間:21 July 2021
作 ???者:Ma B, Xu H, Wang Y, et al.
作者單位:四川大學(xué)?
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34286950/
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7.文章題目:Modeling Nonalcoholic Fatty Liver Disease on a Liver Lobule Chip with Dual Blood Supply.
期 ???刊:Acta Biomaterialia(影響因子:8.947)
發(fā)表時間:13 July 2021
作 ???者:Du K, Li S, Li C, et al.
作者單位:中國科學(xué)技術(shù)大學(xué)
使用產(chǎn)品:Human Albumin ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S174270612100444X
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8.文章題目:Protective effect of isosteviol sodium against LPS-induced multiple organ injury by regulating of glycerophospholipid metabolism and reducing macrophage-driven inflammation.
期 ???刊:Pharmacological Research(影響因子:7.658)
發(fā)表時間:22 July 2021
作 ???者:Wang S, Tan K S, Beng H, et al.
作者單位:廣東工業(yè)大學(xué)
使用產(chǎn)品:Mouse?IL-6, IL-1β and TNF-α ELISA Kits ?
https://www.sciencedirect.com/science/article/abs/pii/S1043661821003650
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9.文章題目:Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals.
期 ???刊:Frontiers in Immunology(影響因子:7.561)
發(fā)表時間:16 July 2021
作 ???者:Qin T, Huang Q, Jiang H, et al.
作者單位:川北醫(yī)學(xué)院附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-a ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34335573/
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10.文章題目:Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis.
期 ???刊:Frontiers in Immunology(影響因子:7.561)
發(fā)表時間:22 July 2021
作 ???者:Qu Y, Li X, Xu F, et al.
作者單位:內(nèi)蒙古醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA Kits???
https://pubmed.ncbi.nlm.nih.gov/34367139/
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11.文章題目:Characterization of the protein structure of soymilk fermented by Lactobacillus and evaluation of its potential allergenicity based on the sensitized-cell model.
期 ???刊:Food Chemistry(影響因子:7.514)
發(fā)表時間:10 July 2021
作 ???者:Lu Q, Zuo L L, Wu Z, et al.
作者單位:南昌大學(xué)?
使用產(chǎn)品:Human IL-6 ELISA Kit ???
https://pubmed.ncbi.nlm.nih.gov/34298394/
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12.文章題目:Overexpression of HOXB4 Promotes Protection of Bone Marrow Mesenchymal Stem Cells Against Lipopolysaccharide-Induced Acute Lung Injury Partially Through the Activation of Wnt/β-Catenin Signaling.
期 ???刊:Journal of Inflammation Research(影響因子:6.922)
發(fā)表時間:19 July 2021
作 ???者:Lin S, Chen Q, Zhang L, et al.
作者單位:中山大學(xué)附屬第一醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-4, IL-6, IL-10 and TNF-α ELISA Kits ?
https://pubmed.ncbi.nlm.nih.gov/34349541/
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13.文章題目:CD90low?glioma-associated mesenchymal stromal/stem cells promote temozolomide resistance by activating FOXS1-mediated epithelial-mesenchymal transition in glioma cells.
期 ???刊:Stem Cell Research & Therapy(影響因子:6.832)?
發(fā)表時間:13 July 2021
作 ???者:Xue B, Xiang W, Zhang Q, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA Kit????
https://pubmed.ncbi.nlm.nih.gov/34256854/
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14.文章題目:Combination Foretinib and anti-PD-1 antibody immunotherapy for colorectal carcinoma.
期 ???刊:Frontiers in Cell and Developmental Biology(影響因子:6.684)
發(fā)表時間:8 July 2021
作 ???者:Fu Y, Peng Y, Zhao S, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse IFN-γ and TNF-α ELISA Kits ???
https://pubmed.ncbi.nlm.nih.gov/34307367/
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15.文章題目:Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
期 ???刊:Frontiers in Cardiovascular Medicine(影響因子:6.05)
發(fā)表時間:7 July 2021
作 ???者:Zhang X M, Gu Y H, Deng H, et al.
作者單位:復(fù)旦大學(xué)附屬浦東醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-6 and TNF-α ELISA Kits ??
https://pubmed.ncbi.nlm.nih.gov/34307504/
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16.文章題目:Anti-inflammatory and Pro-apoptotic Effects of 18beta-Glycyrrhetinic Acid In Vitro and In Vivo Models of Rheumatoid Arthritis.
期 ???刊:Frontiers in Pharmacology(影響因子:5.81)
發(fā)表時間:26 July 2021
作 ???者:Feng Y, Mei L, Wang M, et al.
作者單位:廣州大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β?and IL-6 ELISA Kits ?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351798/
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17.文章題目:Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.
期 ???刊:Aging (Albany NY)(影響因子:5.682)
發(fā)表時間:21 July 2021
作 ???者:Wang B, Li J, Jiao J, et al.
作者單位:上海交通大學(xué)?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34289451/
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18.文章題目:Improvement of Metabolic Syndrome in High-Fat Diet-Induced Mice by Yeast β-Glucan Is Linked to Inhibited Proliferation of Lactobacillus and Lactococcus in Gut Microbiota.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.279)
發(fā)表時間:1 July 2021
作 ???者:Chen G, Chen D, Zhou W, et al
作者單位:南京農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 and IL-10 ELISA Kits??????????
https://pubmed.ncbi.nlm.nih.gov/34197112/
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19.文章題目:An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells.
期 ???刊:Bioorganic Chemistry(影響因子:5.275)
發(fā)表時間:9 July 2021
作 ???者:Yang G J, Song Y Q, Wang W, et al. ?
作者單位:澳門大學(xué)
使用產(chǎn)品:Human IL-6 and IL-8 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34378541/
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20.文章題目:JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis.
期 ???刊:International Immunopharmacology(影響因子:4.932)
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作 ???者:He J, Liu T, Li Y, et al.
作者單位:北京大學(xué)第三醫(yī)院
使用產(chǎn)品:Mouse IL-1β and IL-18 ELISA Kits
樣本類型:海馬體組織
https://www.sciencedirect.com/science/article/pii/S1567576921005981
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21.文章題目:Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus.
期 ???刊:Applied Microbiology and Biotechnology(影響因子:4.813)
發(fā)表時間:28 July 2021
作 ???者:Liu H, Yang N, Teng D, et al.
作者單位:中國農(nóng)業(yè)科學(xué)院飼料研究所
使用產(chǎn)品:Mouse TNF-α, IL-6, IL-1β and MCP-1 ELISA Kits
樣本類型:皮膚組織
https://pubmed.ncbi.nlm.nih.gov/34319418/
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22.文章題目:Fusion Protein Vaccine Based on Ag85B and STEAP1 Induces a Protective Immune Response against Prostate Cancer.
期 ???刊:Vaccines(影響因子:4.422)
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作 ???者:Guo L, Xie H, Zhang Z, et al.
作者單位:天津醫(yī)科大學(xué)第二醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, IL-2 and IL-4 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34358202/
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23.文章題目:Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion.
期 ???刊:PLOS Neglected Tropical Diseases(影響因子:4.411)
發(fā)表時間:8 July 2021
作 ???者:Deng S, Hu X, Luo L, et al.
作者單位:中南大學(xué)湘雅醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-6, IL-12, IL-23, TNF-α and TGF-β1 ELISA Kits
樣本類型:胸腔積液
https://pubmed.ncbi.nlm.nih.gov/34237073/
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24.文章題目:Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-κB signaling.
期 ???刊:Molecular Immunology(影響因子:4.407)
發(fā)表時間:20 July 2021
作 ???者:Wang Y, Liu B, Niu C, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IgE ELISA Kit
https://www.sciencedirect.com/science/article/abs/pii/S016158902100211X
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25.文章題目:The inhibition of GHR enhanced cytotoxic effects of etoposide on neuroblastoma.
期 ???刊:Cellular Signalling(影響因子:4.315)
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作 ???者:Zhang H, Xia H, Chen H, et al.
作者單位:南京醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:IHC kit
https://www.sciencedirect.com/science/article/abs/pii/S0898656821001704
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26.文章題目:Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype.
期 ???刊:International Journal of Medical Sciences(影響因子:3.738)
發(fā)表時間:July 2021
作 ???者:Liu X, Xu Y, Li Y, et al.
作者單位:南京大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/34400883/
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27.文章題目:Muscle-derived mitochondrial transplantation reduces inflammation, enhances bacterial clearance, and improves survival in sepsis.
期 ???刊:Shock(影響因子:3.454)
發(fā)表時間:1 July 2021
作 ???者:Zhang Z, Yan C, Miao J, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-10, KC, MCP-1 and RANTES/CCL5 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/33060455/
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28.文章題目:Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation.
期 ???刊:Pharmacology Research & Perspectives(影響因子:2.794)
發(fā)表時間:29 July 2021
作 ???者:Zheng X F, Chen D D, Zhu X L, et al.
作者單位:華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬協(xié)和醫(yī)院
使用產(chǎn)品:Mouse IL-8 and TNF-α ELISA Kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/34327862/
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29.文章題目:Establishment of a systemic inflammatory response syndrome model and evaluation of the efficacy of umbilical cord mesenchymal stem cell transplantation.
期 ???刊:Cells Tissues Organs(影響因子:2.481)
發(fā)表時間:28 July 2021
作 ???者:Ruan G, Yao X, Mo P, et al.
作者單位:中國人民解放軍聯(lián)勤保障部隊(duì)第920醫(yī)院
使用產(chǎn)品:TNF-α, IL-6 and IL-10 ELISA Kits
https://pubmed.ncbi.nlm.nih.gov/34182545/
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30.文章題目:Exocellular polysaccharides extracted from mangrove fungus Paecilomyces Lilacinuson present anti-HSV-1 activity in mice.
期 ???刊:Journal of Virological Methods(影響因子:2.014)
發(fā)表時間:27 July 2021
作 ???者:Wang J, Huang Y, Lin Y, et al.
作者單位:海南醫(yī)學(xué)院熱帶轉(zhuǎn)化醫(yī)學(xué)實(shí)驗(yàn)室
使用產(chǎn)品:Mouse TNF-α ELISA Kit
樣本類型:大腦組織
https://pubmed.ncbi.nlm.nih.gov/34329630/
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