特發(fā)性肺纖維化(IPF, Idiopathic pulmonary fibrosis)是一種慢性進(jìn)行性間質(zhì)性肺病,最終會(huì)導(dǎo)致肺功能永久惡化并死亡。白細(xì)胞介素-11 (IL-11)是一種促纖維化細(xì)胞因子,對(duì)成纖維細(xì)胞分化為分泌膠原、肌動(dòng)蛋白α2、平滑肌陽性(ACTA2+)肌成纖維細(xì)胞至關(guān)重要,是特發(fā)性肺纖維化(IPF)發(fā)病機(jī)制的驅(qū)動(dòng)過程。最近,上海交通大學(xué)藥學(xué)院在期刊《Science Advances》(IF=14.957)上發(fā)表題為“Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.”的文章,開發(fā)了一種可吸入和可粘液滲透的納米顆粒(NP)系統(tǒng),該系統(tǒng)結(jié)合了抗IL11的siRNA(siIL11 @ PPGC NPs?),并研究了其治療IPF的治療潛力。NP是通過可生物降解的PLGA-PEG二嵌段共聚物和自創(chuàng)的陽離子類脂分子G0-C14的自組裝來配制的,以實(shí)現(xiàn)siIL11的有效跨粘膜遞送。非侵入性霧化吸入通過抑制ERK和SMAD2來阻止成纖維細(xì)胞分化和減少ECM沉積。此外,在博萊霉素誘導(dǎo)的肺纖維化的小鼠模型中,siIL11@PPGC NPs顯著減少了纖維化的發(fā)展并改善了肺功能,而沒有誘導(dǎo)全身毒性。這項(xiàng)研究為siRNA治療劑的局部吸入給藥提供了一個(gè)通用的納米顆粒平臺(tái),并在許多呼吸系統(tǒng)疾病(包括IPF)的治療中顯示出有希望的臨床潛力。
本文中使用了欣博盛Mouse TGF-β1 ELISA kit檢測(cè)了肺泡灌洗液樣本中的表達(dá)量。
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1.文章題目:Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.
期 ???刊:Science Advances(影響因子:14.957)
發(fā)表時(shí)間:22?June?2022
作 ???者:Bai X, Zhao G, Chen Q, et al.
作者單位:上海交通大學(xué)藥學(xué)院?
使用產(chǎn)品:Mouse TGF-β1 ELISA kit
樣本類型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/35731866/
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2.文章題目:Functionalizing multi-component bioink with platelet-rich plasma for customized in-situ bilayer bioprinting for wound healing.
期 ???刊:Materials Today Bio(影響因子:10.761)
發(fā)表時(shí)間:16?June?2022
作 ???者:Zhao M, Wang J, Zhang J, et al.
作者單位:第四軍醫(yī)大學(xué)?
使用產(chǎn)品:Human PDGF-BB ELISA kit
https://www.sciencedirect.com/science/article/pii/S2590006422001326
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3.文章題目:Polysialylated Nanoinducer for Precisely Enhancing Apoptosis and Anti-tumor Immune Response in B-cell Lymphoma.
期 ???刊:Acta Biomaterialia(影響因子:10.633)
發(fā)表時(shí)間:7?June?2022
作 ???者:Zhang Q, Li S, Guo K, et al.
作者單位:四川電子科技大學(xué)?
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35779772/
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4.文章題目:ROS-triggered nanoinducer based on dermatan sulfate enhances immunogenic cell death in melanoma.
期 ???刊:Journal of Controlled Release(影響因子:9.776)?
發(fā)表時(shí)間:1 June?2022
作 ???者:Zhang Q, Li S, Ren J, et al. ?
作者單位:四川電子科技大學(xué)?
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6 and IL-10 ELISA kits?
https://pubmed.ncbi.nlm.nih.gov/35461966/
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5.文章題目:Antibiotics-free nanoparticles eradicate Helicobacter pylori biofilms and intracellular bacteria.
期 ???刊:Journal of Controlled Release(影響因子:9.776)??
發(fā)表時(shí)間:16?June?2022
作 ???者:Zou Y, Chen X, Sun Y, et al.
作者單位:中山大學(xué)藥學(xué)院?
使用產(chǎn)品:Mouse TNF-α ELISA kit?
https://pubmed.ncbi.nlm.nih.gov/35662575/
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6.文章題目:Silver nanoclusters show advantages in macrophage tracing in vivo and modulation of anti-tumor immuno-microenvironment.
期 ???刊:Journal of Controlled Release(影響因子:9.776)??
發(fā)表時(shí)間:5?June?2022
作 ???者:Yan X, Qi Y, Ren L, et al.
作者單位:中國(guó)科學(xué)院生態(tài)環(huán)境科學(xué)研究中心
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35691499/
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7.文章題目:Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure.
期 ???刊:Particle and fibre toxicology(影響因子:9.112)
發(fā)表時(shí)間:23?June?2022
作 ???者:Zhang R, Chen S, Chen L, et al.
作者單位:中山大學(xué)公共衛(wèi)生學(xué)院?
使用產(chǎn)品:Mouse IL-17A and TGF-βELISA kits
樣本類型:肺組織
https://pubmed.ncbi.nlm.nih.gov/35739565/
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8.文章題目:Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
期 ???刊:Critical Care(影響因子:9.097)??
發(fā)表時(shí)間:9?June?2022
作 ???者:Zhang L, Zhang Y, Qin X, et al.
作者單位:重慶醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse IL-6, TNF-α, IL-1β ELISA kits
樣本類型:支氣管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/35681221/
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9.文章題目:A Cell Membrane Repair-Based Nanoformulation with Multiple Actuators for Scarless Wound Healing.
期 ???刊:?Journal of Materials Chemistry B(影響因子:7.571)
發(fā)表時(shí)間:29?June?2022
作 ???者:Zhang X, Wu Z, Sun J, et al.
作者單位:天津醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse IL-1βand IL-6 ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00992g/unauth
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10.文章題目:Dynamic Monitoring of Immunoinflammatory Response Identifies Immunoswitching Characteristics of Severe Acute Pancreatitis in Rats.
期 ???刊:Frontiers in immunology(影響因子:7.561)
發(fā)表時(shí)間:12?June?2022
作 ???者:Zhuang Q, Huang L, Zeng Y, et al.
作者單位:西南醫(yī)科大學(xué)
使用產(chǎn)品:Rat IL-8 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35663952/
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11.文章題目:Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF-α secretion.
期 ???刊:Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease(影響因子:6.633)
發(fā)表時(shí)間:22?June?2022
作 ???者:Liu X, Liang Z, Duan H, et al.
作者單位:南方醫(yī)科大學(xué)公共衛(wèi)生學(xué)院
使用產(chǎn)品:Human TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35752384/
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12.文章題目:Reduced Virulence and Enhanced Host Adaption during Antibiotics Therapy: a Story of a Within-Host Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Evolution in a Patient with a Serious Scrotal Abscess.
期 ???刊:?Msystems(影響因子:6.496)
發(fā)表時(shí)間:1?June?2022
作 ???者:Ye M, Liao C, Shang M, et al.
作者單位:同濟(jì)大學(xué)醫(yī)學(xué)院?
使用產(chǎn)品:Mouse TNF-α, IL-6, and IL-1βELISA kits
https://pubmed.ncbi.nlm.nih.gov/35196132/
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13.文章題目:Integrating inflammation-responsive prodrug with electrospun nanofibers for anti-inflammation application.
期 ???刊:Pharmaceutics(影響因子:6.321)
發(fā)表時(shí)間:13?June?2022
作 ???者:Ye J, Gong M, Song J, et al.
作者單位:北京化工大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://www.mdpi.com/1999-4923/14/6/1273
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14.文章題目:Cinnamaldehyde protect against ligature-induced periodontitis through inhibitions of microbial accumulation and inflammatory responses of host immune cells
期 ???刊:Food & Function(影響因子:6.317)
發(fā)表時(shí)間:22?June?2022
作 ???者:Ou Y, Yan M, Gao G, et al.
作者單位:福建三明大學(xué)?
使用產(chǎn)品:Mouse IL-6, IL-8, IL-1β and TNF-α ELISA kits
樣本類型:牙周組織
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo00963c
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15.文章題目:?Exosomes Derived From Dendritic Cells Infected With Toxoplasma gondii Show Antitumoral Activity in a Mouse Model of Colorectal Cancer.
期 ???刊:Frontiers in oncology(影響因子:6.244)
發(fā)表時(shí)間:7?June?2022
作 ???者:Lu J, Wei N, Zhu S, et al.
作者單位:華南農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse IL-6 and GM-CSF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35600363/
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16.文章題目:Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer.
期 ???刊:Acta Pharmacologica Sinica(影響因子:6.15)
發(fā)表時(shí)間:15?June?2022
作 ???者:Zhao Z, Wang J, Fang L, et al.
作者單位:復(fù)旦大學(xué)藥學(xué)院?
使用產(chǎn)品:Human IgG ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35705687/
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17.文章題目:Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis via modulating gut microbiota dysbiosis and related gut-liver axis activation in CD-1 mice.
期 ???刊:The Journal of Nutritional Biochemistry(影響因子:6.117)
發(fā)表時(shí)間:30?June?2022
作 ???者:Hong T, Jiang X, Zou J, et al.
作者單位:中山大學(xué)公共衛(wèi)生學(xué)院?
使用產(chǎn)品:Mouse TNFα, IL-1β, IL-6 and IL-18 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S095528632200167X
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18.文章題目:?Qiliqiangxin Modulates the Gut Microbiota and NLRP3 Inflammasome to Protect Against Ventricular Remodeling in Heart Failure.
期 ???刊:Frontiers in pharmacology(影響因子:5.988)
發(fā)表時(shí)間:2?June?2022
作 ???者:Lu Y, Xiang M, Xin L, et al.
作者單位:中國(guó)中醫(yī)科學(xué)院?
使用產(chǎn)品:Rat TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35721118/
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19.文章題目:A Type Ib Crustin from Deep-Sea Shrimp Possesses Antimicrobial and Immunomodulatory Activity.
期 ???刊:International Journal of Molecular Sciences(影響因子:5.923)
發(fā)表時(shí)間:7?June?2022
作 ???者:Wang Y J, Sun L.
作者單位:中國(guó)科學(xué)院海洋大科學(xué)中心海洋研究所?
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://www.mdpi.com/1422-0067/23/12/6444
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20.文章題目:Pentapeptide AYP from Isochrysis Zhanjiangensis Exhibits Antiangiogenic Activity in HT1080 Cells and HUVECs by Suppressing Migration and Invasion In Vitro.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時(shí)間:29?June?2022
作 ???者:Tang Y, Yang S, Lin L, et al.
作者單位:廣東海洋大學(xué)?
使用產(chǎn)品:Human VEGF, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35770804/
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21.文章題目:High fluoride ingestion impairs bone fracture healing and attenuating M2 macrophages differentiation.
期 ???刊:Frontiers in Bioengineering and Biotechnology(影響因子:5.89)
發(fā)表時(shí)間:20?June?2022
作 ???者:Du C C, Xiao P, Gao S, et al.
作者單位:重慶醫(yī)科大學(xué)附屬第一醫(yī)院?
使用產(chǎn)品:Mouse CCL2, IL-8, VEGF and TGF-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35669059/
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22.文章題目:Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
期 ???刊:International Immunopharmacology(影響因子:5.714)
發(fā)表時(shí)間:26?June?2022
作 ???者:Deng L, Wang S, Zhang R, et al.
作者單位:廣東工業(yè)大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35767902/
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23.文章題目:Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench.
期 ???刊:Virulence(影響因子:5.428)
發(fā)表時(shí)間:22?June?2022
作 ???者:Wang Y, Zhang J, Yuan Z, et al.
作者單位:中國(guó)科學(xué)院海洋大科學(xué)中心海洋研究所?
使用產(chǎn)品:Mouse IL-1β?and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35733351/
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24.文章題目:The Intracellular Interaction of Porcine β-Defensin 2 with VASH1 Alleviates Inflammation via Akt Signaling Pathway.
期 ???刊:The Journal of Immunology(影響因子:5.422)
發(fā)表時(shí)間:16?June?2022
作 ???者:Huang C, Sun Y, Qiu X, et al.
作者單位:華中農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35688466/
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25.文章題目:Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway.
期 ???刊:Journal of Cellular and Molecular Medicine(影響因子:5.31)
發(fā)表時(shí)間:1 June?2022
作 ???者:Yuan L, Yang J, Li Y, et al.
作者單位:四川大學(xué)華西醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35650472/
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26.文章題目:The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity.
期 ???刊:Scientific reports(影響因子:4.996)
發(fā)表時(shí)間:21?June?2022
作 ???者:Zhang S, Gu C, Huang L, et al.
作者單位:武漢科技大學(xué)?
使用產(chǎn)品:Human IL-6 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35729339/
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27.文章題目:Mechanism of two alkaloids isolated from coral endophytic fungus for suppressing angiogenesis in atherosclerotic plaque in HUVEC.
期 ???刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時(shí)間:5?June?2022
作 ???者:Liu Y, Li Y, Chen M, et al.
作者單位:廣東海洋大學(xué)?
使用產(chǎn)品:Human IL-1β, IL-6, TNF-α and PDGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35704971/
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28.文章題目:PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy.
期 ???刊:Toxicology(影響因子:4.571)
發(fā)表時(shí)間:7?June?2022
作 ???者:Li D, Shen C, Liu L, et al.
作者單位:四川大學(xué)華西醫(yī)院?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-8 ELISA kits
樣本類型:肺泡灌洗液
https://www.sciencedirect.com/science/article/pii/S0300483X22001639
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29.文章題目:Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells.
期 ???刊:?Foods(影響因子:4.35)
發(fā)表時(shí)間:6?June?2022
作 ???者:Wang Z, Wu L, Fu D, et al.
作者單位:大連工業(yè)大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://www.mdpi.com/2304-8158/11/12/1689
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30.文章題目:Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures.
期 ???刊:NeuroToxicology(影響因子:4.294)
發(fā)表時(shí)間:12?June?2022
作 ???者:Zhang J, Su D, Liu Q, et al.
作者單位:貴州中醫(yī)藥大學(xué)?
使用產(chǎn)品:Mouse IL-1β, TNF-α, IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35716928/
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31.文章題目:MCPIP1 promotes cell proliferation, migration and angiogenesis of glioma via VEGFA-mediated ERK pathway.
期 ???刊:Experimental Cell Research(影響因子:4.145)
發(fā)表時(shí)間:19?June?2022
作 ???者:Wang R, Sun S, Wang Z, et al.
作者單位:安徽醫(yī)科大學(xué)?
使用產(chǎn)品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35752346/?
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32.文章題目:PINK1‐mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages.
期 ???刊:Oral Diseases(影響因子:4.068)
發(fā)表時(shí)間:22?June?2022
作 ???者:Jiang K, Li J, Jiang L, et al.
作者單位:南京大學(xué)醫(yī)學(xué)院?
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35730318/?
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33.文章題目:A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization.?
期 ???刊:Experimental Cell Research(影響因子:3.905)??
發(fā)表時(shí)間:12?June?2022
作 ???者:Hou L, Ye Y, Gou H, et al.
作者單位:南京醫(yī)科大學(xué)?
使用產(chǎn)品:Human IL-1β, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35714941/?
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34.文章題目:The stability of dry‐cured ham derived peptides and its anti‐inflammatory effect in RAW264. 7 macrophage cells.
期 ???刊:International Journal of Food Science & Technology(影響因子:3.713)
發(fā)表時(shí)間:7?June?2022
作 ???者:Xing L, Fu L, Toldrá F, et al.
作者單位:南京農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://ifst.onlinelibrary.wiley.com/doi/abs/10.1111/ijfs.15800?
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35.文章題目:Association Between Circulating Cell-Free DNA Level at Admission and the Risk of Heart Failure Incidence in Acute Myocardial Infarction Patients.
期 ???刊:DNA and Cell Biology(影響因子:3.55)
發(fā)表時(shí)間:28?June?2022
作 ???者:Zhang Q, He X, Ling J, et al.
作者單位:湖南省人民醫(yī)院?
使用產(chǎn)品:Human ST2 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35763313/
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36.文章題目:Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage via regulation of the ERK/Nrf2 pathway.
期 ???刊:Journal of Chemical Neuroanatomy(影響因子:3.052)
發(fā)表時(shí)間:8?June?2022
作 ???者:Wang N, Tian Y, Zhao F, et al.
作者單位:首都醫(yī)科大學(xué)?
使用產(chǎn)品:Rat VEGF, MMP-9 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35697268/
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37.文章題目:MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
期 ???刊:?Molecular Biology Reports(影響因子:2.742)
發(fā)表時(shí)間:1?June?2022
作 ???者:Li T, Chen Q, Dai J, et al.
作者單位:重慶醫(yī)科大學(xué)?
使用產(chǎn)品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35644004/
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38.文章題目:Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis.
期 ???刊:Computational and Mathematical Methods in Medicine(影響因子:2.238)??
發(fā)表時(shí)間:5?June?2022
作 ???者:Chen G, Liu X, Luo J, et al.
作者單位:北京中醫(yī)藥大學(xué)?
使用產(chǎn)品:Rat IL-18 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35720033/
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39.文章題目:Generation of a human embryonic stem cell line (SMUDHe010-A-82) carrying a homozygous c. 1538G> A (p. G513D) mutation in the OSMR gene by CRISPR/Cas9-mediated homologous recombination.
期 ???刊:Stem Cell Research(影響因子:2.02)??
發(fā)表時(shí)間:9?June?2022
作 ???者:Zheng W, Zhong Y, Yuan L, et al.
作者單位:南方醫(yī)科大學(xué)?
使用產(chǎn)品:BSA?
https://pubmed.ncbi.nlm.nih.gov/35714449/
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