合成生物學的快速發(fā)展激發(fā)了人們對能夠診斷和治療疾病的工程微生物的興趣。然而,設(shè)計檢測動態(tài)疾病相關(guān)生物標志物的細菌,然后進行驅(qū)動治療仍然很困難。最近,華東理工大學的研究團隊在期刊《Cell Host & Microbe》(IF=31.316)上發(fā)表題為“Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.”的文章,他們開發(fā)了一種工程益生菌,它可以非侵入性地實時監(jiān)測和記錄炎癥性腸病(inflammatory bowel disease,IBD)的發(fā)生和發(fā)展,并可以通過一種自我調(diào)節(jié)的機制來響應這些生物標志物,從而釋放治療藥物。這些用于診斷和治療的智能響應細菌(i-ROBOT)由大腸桿菌Nissle 1917組成,該細菌通過激活堿基編輯系統(tǒng)來產(chǎn)生可遺傳的基因組DNA序列并產(chǎn)生比色信號,從而對炎癥標記物硫代硫酸鹽的水平做出響應。硫代硫酸鹽的波動也驅(qū)動免疫調(diào)節(jié)劑AvCystatin的可調(diào)釋放。給患有結(jié)腸炎的小鼠口服i-ROBOT,在處理過的糞便和結(jié)腸樣品中產(chǎn)生分子記錄信號,并有效改善疾病。i-ROBOT為胃腸和其他代謝疾病提供了一個有前景的設(shè)計思路。
本文中使用了欣博盛Human IL-10和IL-12/23 p40 ELISA kits檢測了細胞培養(yǎng)液上清樣本中這些細胞因子的含量。
1.文章題目:Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.
期 ???刊:Cell Host & Microbe(影響因子:31.316)
發(fā)表時間:27?December 2022
作 ???者:Zou Z P, Du Y, Fang T T, et al.
作者單位:華東理工大學?
使用產(chǎn)品:Human IL-10 and IL-12/23 p40 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S1931312822005765
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2.文章題目:Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis.
期 ???刊:Nature Communications(影響因子:17.694)
發(fā)表時間:19?December 2022
作 ???者:Wang Z, Sun Y, Lou F, et al.
作者單位:上海交通大學
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
樣本類型:皮膚組織
https://pubmed.ncbi.nlm.nih.gov/36535970/
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3.文章題目:Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition.?
期 ???刊:Biomaterials(影響因子:15.304)??
發(fā)表時間:7?December?2022
作 ???者:Zhao L, Rao X, Huang C, et al.
作者單位:廣州醫(yī)科大學?
使用產(chǎn)品:Mouse CXCL10 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36502580/
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4.文章題目:A cyclic heptapeptide-based hydrogel boosts the healing of chronic skin wounds in diabetic mice and patients.
期 ???刊:NPG Asia Materials(影響因子:10.761)
發(fā)表時間:23 December?2022
作 ???者:Fu Z, Sun H, Wu Y, et al.
作者單位:昆明醫(yī)科大學?
使用產(chǎn)品:Mouse TGF-β1 and TNF-α ELISA kits
https://www.nature.com/articles/s41427-022-00444-x
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5.文章題目:Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141.
期 ???刊:International Journal of Biological Macromolecules(影響因子:8.025)??
發(fā)表時間:17?December?2022
作 ???者:Wu K, Li Y, Lin Y, et al.
作者單位:華南農(nóng)業(yè)大學?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits?
https://pubmed.ncbi.nlm.nih.gov/36535356/
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6.文章題目:Involvement of gut-brain communication in arsenite-induced neurobehavioral impairments in adult male mice.
期 ???刊:Ecotoxicology and Environmental Safety(影響因子:7.129)
發(fā)表時間:9 December?2022
作 ???者:Lu Z, Wang F, Xia Y, et al.
作者單位:重慶醫(yī)科大學?
使用產(chǎn)品:Mouse TNF-α ELISA kit
樣本類型:腸和腦組織
https://pubmed.ncbi.nlm.nih.gov/36508802/
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7.文章題目:Perfluorooctane sulfonate promotes atherosclerosis by modulating M1 polarization of macrophages through the NF-κB pathway.
期 ???刊:Ecotoxicology and Environmental Safety(影響因子:7.129)
發(fā)表時間:10?December?2022
作 ???者:Wang D, Tan Z, Yang J, et al.
作者單位:河北醫(yī)科大學?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36512850/
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8.文章題目:Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice.
期 ???刊:Nutrients(影響因子:6.706)
發(fā)表時間:21 December?2022
作 ???者:Yang F, Wang X, Qi J, et al.
作者單位:第四軍醫(yī)大學?
使用產(chǎn)品:Mouse IL-1β ELISA kits
https://www.mdpi.com/2072-6643/15/1/38
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9.文章題目:Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.
期 ???刊:Phytomedicine(影響因子:6.656)
發(fā)表時間:20 December?2022
作 ???者:Zhang H, Yuan Z, Wang J, et al.
作者單位:中國藥科大學?
使用產(chǎn)品:Mouse IFN-γ ELSIA kit
https://www.sciencedirect.com/science/article/pii/S0944711322007085
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10.文章題目:Red raspberry supplementation mitigates alcohol-induced liver injury associated with gut microbiota alteration and intestinal barrier dysfunction in mice.
期 ???刊:Food & Function(影響因子:6.317)
發(fā)表時間:5?December?2022
作 ???者:Zogona D, Zongo A W S, Elkhedir A E, et al.
作者單位:南開大學?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo03245g
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11文章題目:Evaluation of the potential anti-soybean allergic activity of different forms of Lactobacillus delbrueckii subsp. bulgaricus based on cell model in vitro.
期 ???刊:Food & Function(影響因子:6.317)??
發(fā)表時間:6?December?2022
作 ???者:Zhang M, Lu Q, Bai J, et al.
作者單位:南昌大學
使用產(chǎn)品:Human IL-6, IL-8, TNF-α and mouce IFN-γ, IL-4, IL-10 ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo02189g
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12.文章題目:Garlic-derived Exosomes Carrying miR-396e Shapes Macrophage Metabolic Reprograming to Mitigate the Inflammatory Response in Obese Adipose Tissue.
期 ???刊:The Journal of Nutritional Biochemistry(影響因子:6.117)
發(fā)表時間:8?December?2022
作 ???者:Bian Y, Li W, Jiang X, et al.
作者單位:重慶理工大學?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36496060/
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13.文章題目:The Anti-Photoaging Activity of Peptides from Pinctada martensii Meat.
期 ???刊:Marine Drugs(影響因子:6.085)
發(fā)表時間:8?December?2022
作 ???者:Wei M, Qiu H, Zhou J, et al.
作者單位:華南理工大學食品科學與工程學院
使用產(chǎn)品:Human MMP-1?and MMP-3 ELISA kits
https://www.mdpi.com/article/10.3390/md20120770
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14.文章題目:Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-κB/NLRP3 Cascade Response In Vivo.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:6?December?2022
作 ???者:Xia X, Lin H, Luo F, et al.
作者單位:中南林業(yè)科技大學?
使用產(chǎn)品:Rat TNF-α, IL-6, and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36474430/
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15.文章題目:Effect of Structural Targeted Modifications on the Potential Allergenicity of Peanut Allergen Ara h 2.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:27?December 2022
作 ???者:Zhou X, Ren L, Zhang Y, et al.
作者單位:南昌大學?
使用產(chǎn)品:Mouse MCP-1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36574959/
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16.文章題目:Diverse Galactooligosaccharides Differentially Reduce LPS-Induced Inflammation in Macrophages.
期 ???刊:Foods(影響因子:5.561)
發(fā)表時間:8?December?2022
作 ???者:Sun C, Hao B, Pang D, et al.
作者單位:廣東省農(nóng)業(yè)科學院蠶桑農(nóng)業(yè)食品研究所?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://www.mdpi.com/article/10.3390/foods11243973
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17.文章題目:Novel Pectic Polysaccharides Isolated from Immature Honey Pomelo Fruit with High Immunomodulatory Activity.
期 ???刊:Molecules(影響因子:4.927)??
發(fā)表時間:5?December?2022
作 ???者:Hou T, Guo S, Liu Z, et al.
作者單位:華南農(nóng)業(yè)大學?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36500662/
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18.文章題目:Acetyl-CoA Carboxylase (ACC) Inhibitor, CP640186, Effectively Inhibited Dengue Virus (DENV) Infection via Regulating ACC Phosphorylation.
期 ???刊:Molecules(影響因子:4.927)
發(fā)表時間:5?December 2022
作 ???者:Wu W, Chen R, Wan Y, et al.
作者單位:中山大學中山眼科中心?
使用產(chǎn)品:Mouse IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36500675/
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19.文章題目:Differential Foreign Body Reactions between Branched and Linear Glucomannan Scaffolds.
期 ???刊:Journal of Functional Biomaterials(影響因子:4.901)??
發(fā)表時間:11?December?2022
作 ???者:Li Y, Liu Y, Campos de Souza S, et al.
作者單位:澳門大學?
使用產(chǎn)品:Mouse IL-1β ELISA kit?
https://www.mdpi.com/2000288
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20.文章題目:Non–small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment.
期 ???刊:Translational Oncology(影響因子:4.803)
發(fā)表時間:1 December?2022
作 ???者:Chen P, Li Y, Liu R, et al.
作者單位:華中科技大學同濟醫(yī)學院附屬同濟醫(yī)院
使用產(chǎn)品:Mouse IL-6 and IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36463825/
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21.文章題目:Activation of KLF6 by titanate nanofibers and regulatory roles of KLF6 on ATF3 in the endothelial monolayer and mouse aortas.
期 ???刊:Molecular Omics(影響因子:4.212)
發(fā)表時間:20?December 2022
作 ???者:Song F, Li S, Dai X, et al.
作者單位:南華大學?
使用產(chǎn)品:Mouse MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36538054/
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22.文章題目:Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis.
期 ???刊:Molecular Immunology(影響因子:4.174)
發(fā)表時間:9?December?2022
作 ???者:Sun R, Jiang K, Zeng C, et al.
作者單位:廣州醫(yī)科大學?
使用產(chǎn)品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36508750/
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23.文章題目:Inflammatory and pathological changes in Escherichia coli infected mice.
期 ???刊:Heliyon(影響因子:3.776)
發(fā)表時間:24 December?2022
作 ???者:Long N, Deng J, Qiu M, et al.
作者單位:成都醫(yī)學院?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/pii/S240584402203821X
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24.文章題目:Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2.
期 ???刊:Infection and Immunity(影響因子:3.609)
發(fā)表時間:21 December?2022
作 ???者:Xu T, Zheng Y, Liu B, et al.
作者單位:中國農(nóng)業(yè)科學院哈爾濱獸醫(yī)研究所?
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36541752/
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25.文章題目:Mucosal immune responses induced by oral administration of recombinant Lactococcus lactis expressing the S1 protein of PDCoV.
期????刊:Virology(影響因子:3.513)
發(fā)表時間:26?December 2022
作 ???者:Zhai K, Zhang Z, Liu X, et al.
作者單位:中國農(nóng)業(yè)科學院蘭州獸醫(yī)研究所?
使用產(chǎn)品:Mouse IFN-γ, IL-2, IL-4, and IL-17 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0042682222002215
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26.文章題目:Development of a serum-free culture method for endothelial cells of stria vascularis and their pro-inflammatory secretome changes induced by oxidative stress.
期 ???刊:Clinical and Experimental Otorhinolaryngology(影響因子:3.34)
發(fā)表時間:12 December?2022
作 ???者:Yi Y, Wang X R, Chen H T, et al.
作者單位:中山大學附屬第一醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36510681/
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27.文章題目:Gab1 overexpression alleviates doxorubicin-induced cardiac oxidative stress, inflammation, and apoptosis through PI3K/Akt signaling pathway.
期 ???刊:Journal of Cardiovascular Pharmacology(影響因子:3.271)
發(fā)表時間:1?December?2022
作 ???者:Zhang Z, Shen C, Wu N, et al.
作者單位:寧波市第一醫(yī)院?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35856909/
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28.文章題目:Janus kinase inhibitor Tofacitinib alleviated acute hepatitis induced by lipopolysaccharide/D-galactosamine in mice.
期 ???刊:Molecular Biology Reports(影響因子:2.742)
發(fā)表時間:12?December?2022
作 ???者:Zhang X, Lin L, Li L, et al.
作者單位:重慶醫(yī)科大學
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36507969/
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29.文章題目:Shegan Mahuang Decoction May Reduce Airway Inflammation in Neutrophilic Asthmatic Mice by Improving the Mitochondrial Function of Bronchoalveolar Lavage Fluid Exosomes.
期 ???刊:Evidence-Based Complementary and Alternative Medicine(影響因子:2.65)
發(fā)表時間:19 December?2022
作 ???者:Lu H, Fu Z, Chen X, et al.
作者單位:重慶醫(yī)科大學?
使用產(chǎn)品:Mouse IL-4, IL-13, IL-33, and TGF-β ELISA kits
樣本類型:肺泡灌洗液
https://www.hindawi.com/journals/ecam/2022/2477510/
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30.文章題目:Lycium barbarum polysaccharide ameliorates radiation-induced brain injury by regulating gut microbiota.
期 ???刊:Journal of Traditional Chinese Medical Sciences(影響因子:2.547)
發(fā)表時間:2?December?2022
作 ???者:Hu J, Wang C, Li Q, et al.
作者單位:河南大學藥學院?
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/pii/S2095754822001107
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31.文章題目:Manganese and the cGAS–STING Pathway in Infectious Mononucleosis Caused by Epstein-Barr Virus Infection.
期 ???刊:Viral Immunology(影響因子:2.175)??
發(fā)表時間:9?December?2022
作 ???者:Shi J, Li Y, Zhang D, et al.
作者單位:蘇州大學附屬兒童醫(yī)院?
使用產(chǎn)品:Mouse IFN-α and IFN-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36493365/
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32.文章題目:Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients.
期 ???刊:Anais Brasileiros de Dermatologia(影響因子:2.113)
發(fā)表時間:17 December 2022
作 ???者:Farag A G A, Shoeib M A A M, Sleem A S, et al.
作者單位:埃及Shebin EL-koum Menoufia大學?
使用產(chǎn)品:Human?β-Defensin-1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/36535830/
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33.文章題目:Expression and diagnostic value of miR-142-5p and miR-155-5p in the serum of children with allergic rhinitis.
期 ???刊:International Journal of Pediatric Otorhinolaryngology(影響因子:1.626)
發(fā)表時間:19 December?2022
作 ???者:Liu H, Ma G, Xing E, et al.
作者單位:承德醫(yī)科大學附屬醫(yī)院?
使用產(chǎn)品:Human IL-4 ELISA kit
https://www.sciencedirect.com/science/article/abs/pii/S016558762200386X
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34.文章題目:Dexmedetomidine alleviates intestinal barrier dysfunction and inflammatory response in mice via suppressing TLR4/MyD88/NF-κB signaling in an experimental model of ulcerative colitis.
期 ???刊:Folia Histochemica et Cytobiologica(影響因子:1.49)
發(fā)表時間:9?December?2022
作 ???者:Ye X, Xu H, Xu Y.
作者單位:復旦大學附屬金山醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36504132/
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