對乙酰氨基酚(APAP)過量是藥物性肝損傷(DILI)的主要原因。但是目前腸道微生物群和相關(guān)代謝物對APAP和肝功能的影響仍不清楚。最近,南方醫(yī)科大學(xué)團隊在期刊《Cell Host & Microbe》(IF=31.316)上發(fā)表題為“Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.”的文章,該篇研究發(fā)現(xiàn)APAP紊亂與獨特的腸道微生物群落有關(guān),即陰道乳酸桿菌明顯減少。由于細菌β-半乳糖苷酶從飲食中釋放異黃酮大豆苷元,接受陰道毛滴蟲的小鼠顯示出對APAP肝毒性的抗性。用β-半乳糖苷酶抑制劑消除了陰道毛滴蟲對APAP暴露的無菌小鼠的肝保護作用。類似地,β-半乳糖苷酶缺陷型陰道毛滴蟲在APAP處理的小鼠中比野生型小鼠產(chǎn)生更差的結(jié)果,但是這些差異通過大豆苷元給藥得以克服。大豆黃酮阻止了鐵死亡,這與法尼二磷酸合酶(Fdps)表達下降有關(guān),該合酶激活了涉及AKT-GSK3β-Nrf2的關(guān)鍵鐵死亡途徑。該研究證明了陰道乳酸桿菌β-半乳糖苷酶釋放大豆苷元抑制了Fdps介導(dǎo)的肝細胞鐵死亡,為藥物性肝損傷提供了新的治療方法。
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本文中使用了欣博盛Mouse TNF-α, MCP-1 和IL-6 ELISA kits檢測了血漿中這些細胞因子的含量。
1.文章題目:Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
期 ???刊:Cell Host & Microbe(影響因子:31.316)??
發(fā)表時間:25?April?2023
作 ???者:Zeng Y, Wu R, Wang F, et al.
作者單位:南方醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-6, and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37100057/
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2.文章題目:Enhanced Proliferation of Visualizable Mesenchymal Stem Cell–Platelet Hybrid Cell for Versatile Intracerebral Hemorrhage Treatment.
期 ???刊:ACS nano(影響因子:18.027)
發(fā)表時間:10?April?2023
作 ???者:Wu G, Liu Z, Mu C, et al.
作者單位:北京理工大學(xué)?
使用產(chǎn)品:Mouse IL-6, IL-1βand TNF-α ELISA kits
樣本類型:腦組織
https://pubmed.ncbi.nlm.nih.gov/37037487/
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3.文章題目:AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling.
期 ???刊:Nature Communications(影響因子:17.694)
發(fā)表時間:20?April?2023
作 ???者:Da X, Li Z, Huang X, et al.
作者單位:華中科技大學(xué)?
使用產(chǎn)品:Human TGF-β1?ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37081014/
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4.文章題目:Neutrophil-inspired photothermo-responsive drug delivery system for targeted treatment of bacterial infection and endotoxins neutralization.
期 ???刊:Biomaterials Research(影響因子:15.863)??
發(fā)表時間:15?April?2023
作 ???者:Li C, Gan Y, Li Z, et al.
作者單位:中山大學(xué)?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37061741/
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5.文章題目:Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging.
期 ???刊:Science Advances(影響因子:14.957)
發(fā)表時間:12?April?2023
作 ???者:Zhou Y, Yang L, Liu Z, et al.
作者單位:南方醫(yī)科大學(xué)?
使用產(chǎn)品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37043582/
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6.文章題目:Increased reactive oxygen species lead to overactivation of platelets in essential thrombocythemia.
期 ???刊:Thrombosis Research(影響因子:10.407)??
發(fā)表時間:10?April?2023
作 ???者:Dong H, Li H, Fang L, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院血液病研究所
使用產(chǎn)品:Human PF4 ELISA kit;Mouse PF4 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37087805/
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7.文章題目:CXC Chemokine Receptor Type 4 Antagonistic Gold Nanorods Induce Specific Immune Responses and Long-Term Immune Memory to Combat Triple-Negative Breast Cancer.
期 ???刊:ACS Applied Materials & Interfaces(影響因子:10.383)
發(fā)表時間:5?April?2023
作 ???者:Meng Y, Zhou J, Liu X, et al.
作者單位:中國醫(yī)學(xué)科學(xué)院基礎(chǔ)醫(yī)學(xué)研究所?
使用產(chǎn)品:Mouse TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37017641/
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8.文章題目:Donor graft METTL3 gene transfer ameliorates rat liver transplantation ischemia-reperfusion injury by enhancing HO-1 expression in an m6A-dependent manner.
期 ???刊:Clinical Immunology(影響因子:10.19)
發(fā)表時間:6?April?2023
作 ???者:Xiang S, Wang Y, Lei D, et al.
作者單位:重慶醫(yī)科大學(xué)?
使用產(chǎn)品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37030526/
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9.文章題目:Cascade amplification of tumor chemodynamic therapy and starvation with re-educated TAMs via Fe-MOF based functional nanosystem.
期 ???刊:Journal of Nanobiotechnology(影響因子:9.429)
發(fā)表時間:11?April?2023
作 ???者:Zheng X, Li X, Meng S, et al.
作者單位:西北工業(yè)大學(xué)?
使用產(chǎn)品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37041537/
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10.文章題目:Allergenicity reduction of cow milk treated by alkaline protease combined with Lactobacillus Plantarum and Lactobacillus helveticus based on epitopes.?
期 ???刊:Food Chemistry(影響因子:9.231)?
發(fā)表時間:15?April?2023?
作 ???者:Ye M, Xu Z, Tan H, et al. ?
作者單位:南昌大學(xué)
使用產(chǎn)品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37105121/?
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11.文章題目:Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy.
期 ???刊:Journal of Medicinal Chemistry(影響因子:8.039)
發(fā)表時間:20?April?2023
作 ???者:Zhu Y, Zhou M, Cheng X, et al.
作者單位:蘇州大學(xué)?
使用產(chǎn)品:Mouse TNF-α and IL-1β ELISA kits
樣本類型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37078976/
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12.文章題目:Structural characterization and immunomodulatory activity of a polysaccharide from finger citron extracted by continuous phase-transition extraction.
期 ???刊:International Journal of Biological Macromolecules(影響因子:8.025)
發(fā)表時間:17?April?2023
作 ???者:Wang S, Yang Y, Wang Q, et al.
作者單位:華南農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37076066/
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13.文章題目:Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice.
期 ???刊:Food Science and Human Wellness (影響因子:8.022)??
發(fā)表時間:4?April?2023
作 ???者:Xu W, Huang Y, Zhou W, et al.
作者單位:南京農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 and IL-10 ELISA kits?
https://www.sciencedirect.com/science/article/pii/S2213453023000782
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14.文章題目:Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice.
期 ???刊:Food Science and Human Wellness(影響因子:8.022)
發(fā)表時間:4?April?2023
作 ???者:Li J, Guo Y, Ma L, et al.
作者單位:集美大學(xué)?
使用產(chǎn)品:Mouse IFN-γ, ?IL-4, IL-10 and IL-22 ELISA kits
樣本類型:小腸組織
https://www.sciencedirect.com/science/article/pii/S221345302300099X
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15.文章題目:Milk fat globule membrane supplementation protects against β-lactoglobulin-induced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner.
期 ???刊:Food Science and Human Wellness(影響因子:8.022)
發(fā)表時間:14?April?2023
作 ???者:Gong H, Li T, Liang D, et al.
作者單位:中國農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse IFN-γ and IL-4 ELISA kits
https://www.sciopen.com/article/10.26599/FSHW.2022.9250010
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16.文章題目:A manganese-phenolic network platform amplifying STING activation to potentiate MRI guided cancer chemo-/chemodynamic/immune therapy.
期 ???刊:Biomaterials Science(影響因子:7.59)
發(fā)表時間:19?April?2023
作 ???者:Pang X, Fu C, Chen J, et al.
作者單位:華南理工大學(xué)
使用產(chǎn)品:Mouse IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37074080/
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17.文章題目:Sirt4 deficiency promotes the development of atherosclerosis by activating the NF-κB/IκB/CXCL2/3 pathway.
期 ???刊:Atherosclerosis(影響因子:6.847)
發(fā)表時間:21?April?2023
作 ???者:Chang S, Zhang G, Li L, et al.
作者單位:濱州醫(yī)學(xué)院?
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0021915023001764
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18.文章題目:Construction of sandwich ELISA method for quantitative detection of α-lactalbumin in hypoallergenic formula based on a novel monoclonal antibody prepared by the recombinant protein.
期 ???刊:Food Control(影響因子:6.652)
發(fā)表時間:17?April?2023
作 ???者:Tan H, Chen S, Qiu Y, et al.
作者單位:南昌大學(xué)?
使用產(chǎn)品:TMB底物
https://www.sciencedirect.com/science/article/abs/pii/S0956713523002001
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19.文章題目:MiR-126-Loaded Immunoliposomes against Vascular Endothelial Inflammation In Vitro and Vivo Evaluation.
期 ???刊:Pharmaceutics(影響因子:6.525)
發(fā)表時間:30?April?2023
作 ???者:Tang Y, Chen Y, Guo Q, et al.
作者單位:貴州醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse IL-1β and IL-6 ELISA kits
https://www.mdpi.com/1999-4923/15/5/1379
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20.文章題目:A purified fraction of polysaccharides from the fruits of Lycium barbarum L. improves glucose homeostasis and intestinal barrier function in high-fat diet induced mice.
期 ???刊:Food & Function(影響因子:6.317)
發(fā)表時間:10?April?2023
作 ???者:Zhou W, Liu P, Xu W, et al.
作者單位:南京農(nóng)業(yè)大學(xué)?
使用產(chǎn)品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo00262d/unauth
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21.文章題目:Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
期 ???刊:Food & Function(影響因子:6.317)
發(fā)表時間:17?April?2023
作 ???者:Chen F, Chu C, Wang X, et al.
作者單位:東南大學(xué)?
使用產(chǎn)品:Mouse MCP-1 ELISA kit
樣本類型:腸道組織
https://pubmed.ncbi.nlm.nih.gov/37067254/
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22.文章題目:ABCG2 plays a central role in the dysregulation of 25-hydrovitamin D in Crohn's disease.
期 ???刊:The Journal of Nutritional Biochemistry(影響因子:6.117)
發(fā)表時間:21?April?2023
作 ???者:Peng J, Song X, Zhu F, et al.
作者單位:重慶理工大學(xué)?
使用產(chǎn)品:Human CRP, TNF-α, IL-6 and IL-8?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37087072/
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文章題目:Development of a new cellular immunological detection method for tuberculosis based on HupB protein induced IL-6 release test.
期 ???刊:Frontiers in Microbiology(影響因子:6.064)
發(fā)表時間:3?April?2023
作 ???者:Yu X, Jiang S, Li Y, et al.
作者單位:武漢工業(yè)大學(xué)?
使用產(chǎn)品:Human IL-6 and IFN-γ?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37077246/
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24.文章題目:Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation.
期 ???刊:Frontiers in Endocrinology(影響因子:6.055)
發(fā)表時間:1?April?2023
作 ???者:Du T, Xiang L, Zhang J, et al.
作者單位:西南醫(yī)科大學(xué)?
使用產(chǎn)品:Rat TNF-α, IL-6 and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37033263/
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25.文章題目:Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2.
期 ???刊:Frontiers in Pharmacology(影響因子:5.988)
發(fā)表時間:10?April?2023
作 ???者:Zhao S, Sun Y, Wu X, et al.
作者單位:重慶醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-6, and MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37101542/
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26.文章題目:Epitope Mapping of Lysozyme Using the Chinese Egg-Allergic Sera at Both Pooled and Individual Levels.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:13?April?2023
作 ???者:Wang Q, Ju D, Gao J, et al.
作者單位:南昌大學(xué)?
使用產(chǎn)品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37053565/
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27.文章題目:Dextran-Sulfate-Sodium-Induced Colitis-Ameliorating Effect of Aqueous Phyllanthus emblica L. Extract through Regulating Colonic Cell Gene Expression and Gut Microbiomes.
期 ???刊:Journal of Agricultural and Food Chemistry(影響因子:5.895)
發(fā)表時間:27?April?2023
作 ???者:Li X, Ouyang W, Jiang Y, et al.
作者單位:華南理工大學(xué)?
使用產(chǎn)品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37102314/
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28.文章題目:Construction of an Antithrombotic and Anti‐Inflammatory Polyethersulfone Membrane.
期 ???刊:Macromolecular Bioscience(影響因子:5.859)??
發(fā)表時間:14?April?2023
作 ???者:Fu X, Lei T, Tang C, et al.
作者單位:中南大學(xué)?
使用產(chǎn)品:Human CRP, IL-6?and?IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37057668/
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29.文章題目:Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca2+ Entry Pathway.?
期 ???刊:Allergy, Asthma & Immunology Research(影響因子:5.096)??
發(fā)表時間:1 April?2023
作 ???者:Huang J H, Gao H W, Gao D D, et al.
作者單位:澳門科技大學(xué)?
使用產(chǎn)品:Mouse IL-4 ELISA kit
樣本類型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37075798/
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30.文章題目:Subchronic Microcystin-LR Aggravates Colorectal Inflammatory Response and Barrier Disruption via Raf/ERK Signaling Pathway in Obese Mice.
期 ???刊:?Toxins(影響因子:5.075)
發(fā)表時間:1 April?2023
作 ???者:Yang Y, Zheng S, Chu H, et al.
作者單位:中南大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, TNF-α, and IL-10 ELISA kits
https://www.mdpi.com/2072-6651/15/4/262
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31.文章題目:Naproxen-Derived New Compound Inhibits the NF-κB, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264. 7 Cells.
期 ???刊:Molecules(影響因子:4.927)
發(fā)表時間:12?April?2023
作 ???者:Ou Y, You Z, Yao M, et al.
作者單位:五邑大學(xué)?
使用產(chǎn)品:Mouse IL-6 ELISA kit
https://www.mdpi.com/1420-3049/28/8/3395
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32.文章題目:CD40LG and GZMB were correlated with adipose tissue macrophage infiltration and involved in obstructive sleep apnea related metabolic dysregulation: Evidence from bioinformatics analysis.
期 ???刊:Frontiers in Genetics(影響因子:4.772)
發(fā)表時間:1?April?2023
作 ???者:Ming X, Cai W, Li Z, et al.
作者單位:武漢大學(xué)?
使用產(chǎn)品:Human CRP, sCD40L and Granzyme B ELISA kits
https://pubmed.ncbi.nlm.nih.gov/36923793/
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33.文章題目:Electroacupuncture Pretreatment at Zusanli (ST36) Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice by Reducing Oxidative Stress via Activating Vagus Nerve-Dependent Nrf2 Pathway.
期 ???刊:Journal of Inflammation Research(影響因子:4.631)
發(fā)表時間:17?April?2023
作 ???者:Jiang H, Shang Z, You L, et al.
作者單位:上海中醫(yī)藥大學(xué)附屬曙光醫(yī)院?
使用產(chǎn)品:Mouse IL-6, TNF-α, and IL-1β ELISA kits
https://www.tandfonline.com/doi/full/10.2147/JIR.S404087
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34.文章題目:Herbal Medicine Dihydroartemisinin Inhibits Colorectal Cancer by Regulafing PI3K/AKT Signal-ing Pathway.
期 ???刊:Journal of Oncology(影響因子:4.501) ?????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
發(fā)表時間:1?April?2023
作 ???者:Xu J R, Jia F J, Yao G T, et al.
作者單位:香港浸會大學(xué)?
使用產(chǎn)品:Rat TNF-α?ELISA kit
http://journalononcology.org/pdf/1080.pdf
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35.文章題目:Pax6-induced proliferation and differentiation of bone marrow mesenchymal stem cells into limbal epithelial stem cells.
期 ???刊:Stem Cells and Development(影響因子:4.39)
發(fā)表時間:25?April?2023
作 ???者:Gao J, Ding L, Xin Y, et al.
作者單位:貴州醫(yī)科大學(xué)?
使用產(chǎn)品:Mouse TNF-α?ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37097204/
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36.文章題目:Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway.
期 ???刊:Immunology Letters(影響因子:4.23)
發(fā)表時間:29?April?2023
作 ???者:Liu Y, Yuan Y, Zhou Z, et al.
作者單位:電子科技大學(xué)?
使用產(chǎn)品:Mouse IL-17A, IL-6, IFN-γ IL-1β and TNF-α?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37121553/
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37.文章題目:Energy intake restriction significantly improves POCD after internal fixation of tibial fractures in mice.
期 ???刊:American Journal of Translational Research(影響因子:3.94)
發(fā)表時間:1?April?2023
作 ???者:Xie W, Sun J, Zheng J, et al.
作者單位:福建醫(yī)科大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-6, IL-8 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37056861/
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38.文章題目:Enhanced anti-rheumatoid arthritis activity of total alkaloids from Picrasma quassioides in collagen-induced arthritis rats by a targeted drug delivery system.
期 ???刊:Journal of Pharmaceutical Sciences(影響因子:3.784)
發(fā)表時間:5?April?2023
作 ???者:Yuan H, Liu B, Liu F, et al.
作者單位:中國藥科大學(xué)?
使用產(chǎn)品:Mouse IL-6 and TNF-α?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37023852/
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39.文章題目:DDB1 regulates the activation-induced apoptosis of T cells via downregulating the expression of histone methyltransferase SETD7.
期 ???刊:Medical Oncology(影響因子:3.738)
發(fā)表時間:12?April?2023
作 ???者:Wu R, Wu X, Zou L, et al.
作者單位:江南大學(xué)?
使用產(chǎn)品:Mouse TNF-α?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37043057/
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40.文章題目:Betaine regulates adipogenic and osteogenic differentiation of hAD-MSCs.
期 ???刊:Molecular Biology Reports(影響因子:2.742)
發(fā)表時間:26?April?2023
作 ???者:Jing Y, Zhou J, Guo F, et al.
作者單位:沈陽化工大學(xué)?
使用產(chǎn)品:Mouse IL-6 and TNF-α?ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37101008/
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41.文章題目:Different effects of a perioperative single dose of dexamethasone on wound healing in mice with or without sepsis.
期 ???刊:Frontiers in Surgery(影響因子:2.568)
發(fā)表時間:11?April?2023
作 ???者:Chen Y, Chen X, Zhou Q.
作者單位:上海交通大學(xué)附屬醫(yī)院?
使用產(chǎn)品:Mouse IL-6, TNF-α, and IL-10 ELISA kits
樣本類型:皮膚組織
https://pubmed.ncbi.nlm.nih.gov/37114154/
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42.文章題目:Effects of irradiation with different fractionations on radioresistant esophageal cancer cells and lung tissues.
期 ???刊:Journal of Radiation Research and Applied Sciences(影響因子:1.773)
發(fā)表時間:18?April?2023
作 ???者:Wang L, Xu S, Yang B, et al.
作者單位:重慶大學(xué)
使用產(chǎn)品:Mouse TGF-β1 ELISA kit
https://www.sciencedirect.com/science/article/pii/S1687850723000523
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43.文章題目:Porcine Deltacoronavirus-like Particles Produced by a Single Recombinant Baculovirus Elicit Virus-Specific Immune Responses in Mice.
期 ???刊:Viruses(影響因子:1.723)
發(fā)表時間:29?April?2023
作 ???者:Liu Y, Han X, Qiao Y, et al.
作者單位:南陽師范學(xué)院?
使用產(chǎn)品:Mouse IFN-γ and IL-4 ELISA kits
https://www.mdpi.com/1999-4915/15/5/1095
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44.文章題目:Role of activating the nuclear factor kappa B signaling pathway in the development of septic cardiomyopathy in rats with sepsis.
期 ???刊:Technology and Health Care(影響因子:1.205)
發(fā)表時間:21?April?2023
作 ???者:Xing X R, Luo L P, Li Y L, et al.
作者單位:江蘇科技大學(xué)
使用產(chǎn)品:Rat TNF-α, IL-1βand IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37092189/
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