近期,西安交通大學(xué)第一附屬醫(yī)院陳超教授、侯鵬教授及其團(tuán)隊(duì)合作在《Aggregate》(IF=18.8)上發(fā)表題為?“Smart multi-functional aggregates reoxygenate tumor microenvironment through a two-pronged strategy to revitalize cancer immunotherapy”(智能多功能聚合體通過(guò)雙管齊下的策略使腫瘤微環(huán)境重新充氧,以促進(jìn)癌癥免疫治療)的研究。PD-1/PD-L1抑制劑已成為晚期實(shí)體瘤的標(biāo)準(zhǔn)治療方法;然而,總體反應(yīng)率低與系統(tǒng)性副作用等挑戰(zhàn)阻礙了其實(shí)施。缺氧促使腫瘤微環(huán)境的重塑是免疫療法失敗的主要原因。盡管目前已經(jīng)報(bào)道了一些緩解缺氧的策略,但它們的個(gè)體局限性限制了進(jìn)一步的改進(jìn)。本文中,研究團(tuán)隊(duì)提出了一種新穎的雙管齊下的策略,通過(guò)同時(shí)采用阿托伐醌(ATO,抑制氧消耗)和氧合血紅蛋白(HbO2,直接補(bǔ)充氧氣)在名為?NPs-aPD-1/HbO2/ATO的多功能聚合體中有效地解決缺氧問(wèn)題。除了用這兩種成分消除缺氧外,這種智能聚合體還包括白蛋白和?ROS?響應(yīng)交聯(lián)劑作為控釋支架,以及用于免疫治療的?PD-1?抗體?(aPD-1)。有趣的是,NPs-aPD-1/HbO2/ATO?在體內(nèi)表現(xiàn)出特殊的腫瘤靶向性,在腫瘤中的積累量比在肝臟中高約?4.2?倍。因此,這種聚合體不僅有效緩解缺氧并顯著輔助aPD-1免疫治療,而且同時(shí)解決了與每個(gè)成分單獨(dú)給藥相關(guān)的靶向和全身毒性問(wèn)題。這項(xiàng)研究對(duì)藥物靶向遞送、解決腫瘤缺氧和推進(jìn)免疫治療具有重要的意義,為推進(jìn)癌癥治療策略提供了有價(jià)值的見(jiàn)解。
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(圖1:NPs-aPD-1/HbO2/ΑTO合成與功能示意圖)
在該項(xiàng)研究中,使用了欣博盛生物(NeoBioscience Technology Co, Ltd)的Mouse IgG ELISA kit,用于檢測(cè)NPs-aPD-1/HbO2/ATO培養(yǎng)上清液中IgG的含量。
貨號(hào) | 產(chǎn)品名稱(chēng) | 靈敏度 | 檢測(cè)范圍 |
EMC116 |
QuantiCyto?Mouse IgG(Total) ELISA Kit(小鼠總免疫球蛋白G) | 0.08ng/ml | 0.156-10ng/ml |
欣博盛生物非常榮幸能夠作為供應(yīng)商為該項(xiàng)研究提供高品質(zhì)ELISA試劑盒,為生物醫(yī)學(xué)領(lǐng)域的科研探索貢獻(xiàn)一份力量。
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1.?Smart multi-functional aggregates reoxygenate tumor microenvironment through a two-pronged strategy to revitalize cancer immunotherapy(Aggregate, IF=18.8)
發(fā)表時(shí)間:2024/3/20
作者:Zhang Y, Liang L, Li H, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IgG ELISA kit
https://onlinelibrary.wiley.com/doi/10.1002/agt2.545?af=R
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2.?Elaboration a ROS-responsive darutigenol prodrug nanoassemblies for inflammatory arthritis treatment(Nano Today, IF=17.4)
發(fā)表時(shí)間:2024/3/6
作者:Yan H, Wang D, Tian C, et al.
作者單位:沈陽(yáng)藥科大學(xué)
使用產(chǎn)品:Mouse TNF-α and IL-6 Elisa kits
https://www.sciencedirect.com/science/article/abs/pii/S1748013224000756
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3.?Molecular Engineering of Activatable NIR-II Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Inflammatory Bowel Disease(ACS Nano, IF=17.1)
發(fā)表時(shí)間:2024/3/4
作者:Liu Y, Diao S, Ruan B, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38501308/
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4.?Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition(Nature Communications, IF=16.6)
發(fā)表時(shí)間:2024/3/29
作者:Zhou M, Liu C, Li B, et al.
作者單位:四川大學(xué)華西藥學(xué)院
使用產(chǎn)品:Human/Mouse/Rat HMGB1 ELISA Kit
https://pubmed.ncbi.nlm.nih.gov/38553476/
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5.?Metabolism/Immunity Dual-Regulation Thermogels Potentiating Immunotherapy of Glioblastoma Through Lactate-Excretion Inhibition and PD-1/PD-L1 Blockade(Advanced Science, IF=15.1)
發(fā)表時(shí)間:2024/3/9
作者:Li T, Xu D, Ruan Z, et al.
作者單位:武漢大學(xué)中南醫(yī)院
使用產(chǎn)品:Mouse IFN-γ, TNF-α and TGF-β ELISA kits
樣本類(lèi)型:腫瘤組織勻漿
https://pubmed.ncbi.nlm.nih.gov/38460167/
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6.?Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice(Acta Pharmaceutica Sinica B, IF=14.5)
發(fā)表時(shí)間:2024/3/22
作者:Li D, Wei R, Zhang X, et al.
作者單位:南方醫(yī)科大學(xué)
使用產(chǎn)品:Mouse TNF-α , IL-1β and IL-6 ELISA kits
https://www.sciencedirect.com/science/article/pii/S2211383524001060
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7.?Self-Assembled DNA Composite‐Engineered Mesenchymal Stem Cells for Improved Skin-Wound Repair(Small, IF=13.3)
發(fā)表時(shí)間:2024/3/5
作者:Li Z, Wang Y, Wang H, et al.
作者單位:中國(guó)醫(yī)學(xué)科學(xué)院
使用產(chǎn)品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38441385/
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8.?Scale-Up Preparation of Manganese‐Iron Prussian Blue Nanozymes as Potent Oral Nanomedicines for Acute Ulcerative Colitis(Advanced Healthcare Materials, IF=10)
發(fā)表時(shí)間:2024/3/6
作者:Hu C, Yuan X, Zhao R, et al.
作者單位:中國(guó)科學(xué)技術(shù)大學(xué)
使用產(chǎn)品:Mouse IL-1β ELISA kit
樣本類(lèi)型:結(jié)腸組織
https://pubmed.ncbi.nlm.nih.gov/38447228/
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9.?Maresin-1 ameliorates hypertensive vascular remodeling through its receptor LGR6(MedComm, IF=9.9)
發(fā)表時(shí)間:2024/3/9
作者:Yin Z, Zhang J, Zhao M, et al.
作者單位:武漢大學(xué)人民醫(yī)院
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38463394/
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10.?Combined Amniotic Membrane and Self-Powered Electrical Stimulator Bioelectronic Dress Promotes Wound Healing(ACS Applied Materials & Interfaces, IF=9.5)
發(fā)表時(shí)間:2024/3/21
作者:Wang Y, Wu H, Xiao A, et al.
作者單位:甘肅省中心醫(yī)院
使用產(chǎn)品:Human VEGF ELISA kit
樣本類(lèi)型:條件培養(yǎng)基
https://pubmed.ncbi.nlm.nih.gov/38515315/
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11.?Investigation into potential allergenicity of DBD plasma-treated casein digestion products based on immunoglobulin E linear epitopes and the sensitized-cell model(Food Chemistry, IF=8.8)
發(fā)表時(shí)間:2024/3/5
作者:Zhang Y, Ren E F, Wen T, et al.
作者單位:廣西大學(xué)
使用產(chǎn)品:Human IL-4, IL-6, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38484545/
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12.?Cyperus peptide SFRWQ inhibits oxidation and inflammation in RAW264.7 cell model(International Journal of Biological Macromolecules, IF=8.2)
發(fā)表時(shí)間:2024/3/31
作者:Ma C, Wu X.
作者單位:內(nèi)蒙古大學(xué)
使用產(chǎn)品:Human/Mouse CXCL4 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38565370/
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13.?Oxyimperatorin attenuates LPS-induced microglial activation in vitro and in vivo via suppressing NF-κB p65 signaling(Biomedicine & Pharmacotherapy, IF=7.5)
發(fā)表時(shí)間:2024/3/6
作者:Lu C, Huang C, Qu S, et al.
作者單位:澳門(mén)大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-10, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38452656/
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14.?Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury(Biomedicine & Pharmacotherapy, IF=7.5)
發(fā)表時(shí)間:2024/3/28
作者:Liu Y G, Zhang S S, Jin S W, et al.
作者單位:中國(guó)醫(yī)學(xué)科學(xué)院
使用產(chǎn)品:Mouse IL-38/IL-1F10 ELISA kit
樣本類(lèi)型:支氣管灌洗液
https://pubmed.ncbi.nlm.nih.gov/38552441/
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15.?Design and Synthesis of 3-(2H-Chromen-3-yl)-5-aryl-1,2,4-oxadiazole Derivatives as Novel Toll-like Receptor 2/1 Agonists That Inhibit Lung Cancer In Vitro and In Vivo(Journal of Medicinal Chemistry, IF=7.3)
發(fā)表時(shí)間:2024/3/18
作者:Wang Y, Cheng X, Liu X, et al.
作者單位:放射醫(yī)學(xué)研究所
使用產(chǎn)品:Mouse IL-6 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38498304/
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16.?Dibutyl phthalate (DBP) promotes Epithelial-Mesenchymal Transition (EMT) to aggravate liver fibrosis into cirrhosis and portal hypertension (PHT) via ROS/TGF-β1/Snail-1 signalling pathway in adult rats(Ecotoxicology and Environmental Safety, IF=6.8)
發(fā)表時(shí)間:2024/3/18
作者:Chen M, Wu G B, Hua S, et al.
作者單位:上海交通大學(xué)附屬醫(yī)院
使用產(chǎn)品:Rat TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38503108/
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17.?Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation(Inflammation Research, IF=6.7)
發(fā)表時(shí)間:2024/3/12
作者:Li Y, Fu W, Xiang J Y, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse IgE ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38472395/
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18.?Litchi pulp-derived gamma-aminobutyric acid (GABA) extract counteracts liver inflammation induced by litchi thaumatin-like protein(Food & Function, IF=6.1)
發(fā)表時(shí)間:2024/3/26
作者:Wang Y, Wang D, Wang K, et al.
作者單位:華南農(nóng)業(yè)大學(xué)
使用產(chǎn)品:Mouse IL-6, IL-8, IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38606579/
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19.?Label-free Raman imaging for screening of anti-inflammatory function food(Food Chemistry: X, IF=6.1)
發(fā)表時(shí)間:2024/3/16
作者:Zeng Q, Peng Y, Zhou X, et al.
作者單位:西安電子科技大學(xué)
使用產(chǎn)品:Mouse IL-1β and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38544930/
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20.?Extracellular vesicles derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer(iScience, IF=5.8)
發(fā)表時(shí)間:2024/3/26
作者:Xie J, Xing S, Jiang H, et al.
作者單位:廣東省中山市人民醫(yī)院
使用產(chǎn)品:Human CXCL4 and Mouse CXCL4 ELISA kits
樣本類(lèi)型:細(xì)胞外囊泡
https://www.sciencedirect.com/science/article/pii/S2589004224008344
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21.?Multiple effects of dose-related GM-CSF on periodontal resorption in deep-frozen grafted teeth: A reverse study(International Immunopharmacology, IF=5.6)
發(fā)表時(shí)間:2024/3/1
作者:Chen Y, Zhou M, Liu J, et al.
作者單位:電子科技大學(xué)附屬四川省人民醫(yī)院
使用產(chǎn)品:Human GM-CSF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38430803/
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22.?High-fat diet-induced obesity causes intestinal Th17/Treg imbalance that impairs the intestinal barrier and aggravates anxiety-like behavior in mice(International Immunopharmacology, IF=5.6)
發(fā)表時(shí)間:2024/3/7
作者:Cai Y, Deng W, Yang Q, et al.
作者單位:中山大學(xué)附屬第六醫(yī)院
使用產(chǎn)品:Mouse TGF-β, IL-10, IL-17 and IL-22 ELISA kits
樣本類(lèi)型:腸組織
https://pubmed.ncbi.nlm.nih.gov/38514921/
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23.?Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing(International Immunopharmacology, IF=5.6)
發(fā)表時(shí)間:2024/3/7
作者:Kong Q, Gao S, Li P, et al.
作者單位:中山大學(xué)光華口腔醫(yī)學(xué)院附屬口腔醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38452411/
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24.?Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the β‐common receptor in mice with cerebral ischemic stroke(CNS Neuroscience & Therapeutics, IF=5.5)
發(fā)表時(shí)間:2024/3/15
作者:Wang R L, Yang Z H, Huang Y Y, et al.
作者單位:首都醫(yī)科大學(xué)宣武醫(yī)院
使用產(chǎn)品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
樣本類(lèi)型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38488446/
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25.?Integrative analysis of network pharmacology and proteomics reveal the protective effect of Xiaoqinglong Decotion on neutrophilic asthma(Journal of Ethnopharmacology, IF=5.4)
發(fā)表時(shí)間:2024/3/30
作者:Liao G, Yan Q, Zhang M, et al.
作者單位:深圳市中西醫(yī)結(jié)合醫(yī)院
使用產(chǎn)品:Mouse IgE and IL-8 ELISA kits
樣本類(lèi)型:支氣管灌洗液
https://pubmed.ncbi.nlm.nih.gov/38561057/
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26.?Molecular identification and probiotic potential characterization of lactic acid bacteria isolated from the pigs with superior immune responses(Frontiers in Microbiology, IF=5.2)
發(fā)表時(shí)間:2024/3/21
作者:Ma W, Zhang W, Wang X, et al.
作者單位:中國(guó)農(nóng)業(yè)科學(xué)院哈爾濱獸醫(yī)研究所
使用產(chǎn)品:Mouse TNF-α ELISA kit
樣本類(lèi)型:常規(guī)組織
https://pubmed.ncbi.nlm.nih.gov/38585699/
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27.?Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells(Inflammation, IF=5.1)
發(fā)表時(shí)間:2024/3/18
作者:Ren C, Wang Q, Fan S, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Mouse and human IL-1β and IL-18 ELISA kits
樣本類(lèi)型:肺組織
https://pubmed.ncbi.nlm.nih.gov/38498270/
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28.?TolDC Restores the Balance of Th17/Treg via Aryl Hydrocarbon Receptor to Attenuate Colitis(Inflammatory Bowel Diseases, IF=4.9)
發(fā)表時(shí)間:2024/3/2
作者:Wang S, Xu Y, Wang L, et al.
作者單位:南京醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TGF-β and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38431309/
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29.?Chlojaponilactone B Attenuates THP-1 Macrophage Pyroptosis by Inhibiting the TLR/MyD88/NF-κB Pathway(Pharmaceuticals, IF=4.6)
發(fā)表時(shí)間:2024/3/21
作者:Wen Q, Zhan B, Jin L, et al.
作者單位:中山大學(xué)
使用產(chǎn)品:Mouse IL-1β, IL-18, TNF-α, and IL-6 ELISA kits; Human caspase-1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38543188/
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30.?Leukemia inhibitory factor protects against experimental periodontitis through immuno-modulations of both macrophages and periodontal ligament fibroblasts(Journal of Periodontology, IF=4.3)
發(fā)表時(shí)間:2024/3/15
作者:Ou Y, Fan L, Wang X, et al.
作者單位:武漢大學(xué)口腔醫(yī)學(xué)院
使用產(chǎn)品:Mouse IL-6, MMP-13, IL-1β and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38488753/
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31.?ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis(World Journal of Gastroenterology, IF=4.3)
發(fā)表時(shí)間:2024/3/28
作者:Zhang T, Zhu S, Huang G W.
作者單位:中南大學(xué)湘雅醫(yī)院
使用產(chǎn)品:Mouse IL-6, IL-1β, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38617741/
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32.?Heat/non-heat treatment alleviate β‐conglycinin‐triggered food allergy reactions by modulating the Th1/Th2 immune balance in a BALB/c mouse model(Journal of the Science of Food and Agriculture, IF=4.1)
發(fā)表時(shí)間:2024/3/22
作者:Zhang T, Zhu S, Huang G W.
作者單位:河南工業(yè)大學(xué)
使用產(chǎn)品:Mouse IgG (Total), IgE, IgG1, IgG2a, IL-4, IL-5, IL-10, IL-12, IL-13, IFN-γ and JE/MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38517196/
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33.?Protective effects of docosahexaenoic acid supplementation on cognitive dysfunction and hippocampal synaptic plasticity impairment induced by early postnatal PM2.5 exposure in young rats(Naunyn-Schmiedeberg's Archives of Pharmacology, IF=3.6)
發(fā)表時(shí)間:2024/3/9
作者:Gui J, Xie M, Wang L, et al.
作者單位:重慶醫(yī)科大學(xué)附屬兒童醫(yī)院
使用產(chǎn)品:Rat IL-1β and IL-6 ELISA kits
樣本類(lèi)型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38459987/
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34.?CD5L induces inflammation and survival in RA-FLS through ERK1/2 MAPK pathway(Autoimmunity, IF=3.5)
發(fā)表時(shí)間:2024/2/29
作者:Yang H, Luo Y, Lai X.
作者單位:重慶醫(yī)科大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:Mouse IL-6, IL-8, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38425093/
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35.?CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle(Oncology Letters, IF=2.9)
發(fā)表時(shí)間:2024/3/13
作者:Zhou H Y, Wang Y C, Wang T, et al.
作者單位:西安交通大學(xué)第一附屬醫(yī)院
使用產(chǎn)品:HRP- Streptavidin
https://pubmed.ncbi.nlm.nih.gov/38516683/
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36.?Evaluation of canine adipose-derived mesenchymal stem cells for neurological functional recovery in a rat model of traumatic brain injury(BMC Veterinary Research, IF=2.6)
發(fā)表時(shí)間:2024/3/18
作者:Jiang W, Luo H, Zhao M, et al.
作者單位:廣東省嶺南現(xiàn)代農(nóng)業(yè)科技實(shí)驗(yàn)室
使用產(chǎn)品:Mouse IL-6, TNF-α and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/38500105/
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37.?Association between chitinase-3-like protein 1 and metabolic-associated fatty liver disease in patients with type 2 diabetes mellitus(Irish Journal of Medical Science, IF=2.1)
發(fā)表時(shí)間:2024/3/23
作者:Zhang F, Han Y, Zheng L, et al.
作者單位:常州市第三人民醫(yī)院
使用產(chǎn)品:Human IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38520612/
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38.?Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota(Biological and Pharmaceutical Bulletin, IF=2)
發(fā)表時(shí)間:2024/3/22
作者:Zhou L, Zhang C L, Jiang K, et al.
作者單位:江西中醫(yī)藥大學(xué)
使用產(chǎn)品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/38522942/
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39.?Dihydroergotamine protects against ischemic stroke by modulating microglial/macrophage polarization and inhibiting inflammation in mice(Neurological Research, IF=1.9)
發(fā)表時(shí)間:2024/3/11
作者:Zheng Y, Hu Y, Yan F, et al.
作者單位:首都醫(yī)科大學(xué)宣武醫(yī)院
使用產(chǎn)品:Mouse IL-1β and TNF-α ELISA kits
樣本類(lèi)型:腦組織
https://pubmed.ncbi.nlm.nih.gov/38468466/
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40.?Generation of a human embryonic stem cell line (SMUDHe010-A-1A) carrying Brainbow cassette in the AAVS1 gene by CRISPR/Cas9-mediated homologous recombination(Stem Cell Research, IF=1.2)
發(fā)表時(shí)間:2024/3/11
作者:Luo Y, Zheng W, Zhong Y, et al.
作者單位:南方醫(yī)科大學(xué)附屬醫(yī)院
使用產(chǎn)品:BSA
https://pubmed.ncbi.nlm.nih.gov/38507883/
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41.?Irg1/itaconate activates Nrf2/HO-1 pathway and mitigates septic liver injury in mice(European Journal of Inflammation, IF=0.7)
發(fā)表時(shí)間:2024/3/21
作者:Zhang T, Li K, Qiu J, et al.
作者單位:重慶醫(yī)科大學(xué)附屬大學(xué)城醫(yī)院
使用產(chǎn)品:Mouse TNF-α and IL-6 ELISA kits
https://www.researchgate.net/publication/379174311_Irg1itaconate_activates_Nrf2HO-1_pathway_and_mitigates_septic_liver_injury_in_mice
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