| ?編號 | ?產(chǎn)品名稱 | ?功能 | ?純度 |
| ?14489 | ?ASH1L?bromodomain?(humanre?
?combinant) | ?ASH1L?is?a?histone?methyltransferase?that?
?regulates?mammalian?Hox?gene?expression,?
?which?plays?an?important?role?in?haemato-
?poietic?development?in?mammals. | ?≥90% |
| ?14490 | ?ATAD2?bromodomain?(human?
?recombinant) | ?ATAD2?is?an?AAA+?ATPase-containing?nuclear?
?transcriptional?coactivator?for?estrogen?and?
?androgen?receptors.?Its?bromodomain?
?associates?with?acetylated?lysine?14?on?histone?
?H3?to?regulate?the?genes?required ?for?cell?cycle?
?progression. | ?≥90% |
| ?11917 | ?BAZ2B?bromodomain?(human?
?recombinant) | ?A?rare?allele?of?BAZ2B?has?been?identified?to?be?
?a?predictor?of?Sudden?Cardiac?Death. | ?≥80% |
| ?11918 | ?BPTF?bromodomain?(human?
?recombinant) | ?BPTF?is?the?largest?component?of?the?NURF?
?chromation?remodeling?complex.Its?
?bromodomain?recognizes?acetylation?of?lysines?
?in?histone?4. | ?≥80% |
| ?11507 | ?BRD1?bromodomain?(human?
?recombinant) | ?BRD1?has?been?identified?as?a?susceptibility?
?gene?in?neurological?disorders,?such?as?
?schizophrenia?and?bipolar?affective?disorder. | ?≥95% |
| ?11071 | ?BRD2?bromodomain1?(human?
?recombinant;?GST-tagged) | ?A?member?of?the?BET?protein?family,?which?
?plays?a?key?role?in?many?processes.?The?
?bromodomains?of?BRD2?bind?acetylated?
?histone?tails,?coupling?histone?acetylation?
?marks?to?the?transcriptional?regulation?of?target?
?promoters. | ?≥95% |
| ?11070 | ?BRD2?bromodomain?2?(human?
?recombinant;GST-tagged) | ?See?Item?No.?11071?for?details. | ?≥95% |
| ?11069 | ?BRD2?bromodomains?1?and?2?(human?
?recombinant;GST-tagged) | ?See?Item?No.?11071?for?details. | ?≥90% |
| ?11285 | ?BRD3?bromodomain?1?(human?
?recombinant) | ?The?BET?proteins?play?a?key?role?in?many?
?cellular?processes,?including?inflammatory?
?gene?expression,?mitosis,?and?viral/host?
?interactions.The?bromodomains?of?BRD3?bind?
?acetylated?histone?tails,?coupling?histone?
?acetylation?marks?to?the?transcriptional?
?regulation?of?target?promoters. | ?≥95% |
| ?14658 | ?BRD3?bromodomain?2?(human?
?recombinant) | ?See?Item?No.?11285?for?details. | ?≥95% |
| ?14864 | ?BRD3?bromodomain?1?and?2?(human?
?recombinant) | ?See?Item?No.?11285?for?details. | ?≥95% |
| ?11068 | ?BRD4?bromodomain?1?(human?
?recombinant;?GST-tagged) | ?The?BET?proteins?play?a?key?role?in?many?
?cellular?processes,?including?inflammatory?
?gene?expression,?mitosis,?and?viral/host?
?interactions.The?bromodomains?of?BRD4?bind?
?acetylated?histone?tails,?serving?to?couple?
?histone?acetylation?marks?to?the?transcriptional?
?regulation?of?target?promoters. | ?≥60% |
| ?11720 | ?BRD4?bromodomain?1?(human?
?recombinant;?His-tagged) | ?See?Item?No.?11068?for?details. | ?≥95% |
| ?11066 | ?BRD4?bromodomain?2?(human ?
?recombinant;?GST-tagged) | ?See?Item?No.?11068?for?details. | ?≥95% |
| ?11721 | ?BRD4?bromodomain?2?(human?
?recombinant;?His-tagged) | ?See?Item?No.?11068?for?details. | ?≥95% |
| ?14822 | ?BRD4?bromodomains?1?and?2?(human?
?recombinant;?aa2-477) | ?See?Item?No.?11068?for?details. | ?≥70% |
| ?11052 | ?BRD4?bromodomains?1?and?2?(human?
?recombinant;?aa49-460) | ?See?Item?No.?11068?for?details. | ?≥90% |
| ?14491 | ?BRD7?bromodomain?(human?
?recombinant) | ?BRD7?is?subunit?of?the?polybromo-associated?
?BRG1-associated?factor(PBAF)-specific?
?component?of?the?switch/sucrose?nonfermen-
?table?chromation-remodeling?complex.It?has?a?
?tumor?suppressor?role?by?acting?as?a?cofactor?
?for?p53?and?regulating?breast?cancer?tumori-
?genicity. | ?≥90% |
| ?11509 | ?BRD9?bromodomain?(human?
?recombinant) | ?Human?BRD9?contains?a?single?bromodomain?
?and?has?five?isoforms?that?are?produced?by?
?alternative?splicing. | ?≥95% |
| ?11548 | ?BRDT?bromodomain?1?(human?
?recombinant) | ?BRDT?shares?homology?with?RING3?protein.?
?The?two?bromodomains?of?BRDT?recognize?
?acetylated?histone?H4,?Loss?of?BRDT?leads?to?
?defects?in?spermatogenesis. | ?≥95% |
| ?11649 | ?BRDT?bromodomain?2?(human?
?recombinant) | ?See?Item?No.?11548?for?details. | ?≥95% |
| ?14492 | ?BRDT?bromodomains?1?and?2?(human?
?recombinant) | ?See?Item?No.?11548?for?details. | ?≥95% |
| ?11284 | ?BRG1?bromodomain?(human?
?recombinant) | ?BRG1?is?a?member?of?the?SWI/SNF?proteins?
?family,?which?forms?part?of?the?large?ATP-
?dependent?chromatin?remodeling?complex?that?
?is?requires?for?transciptional?activation?of?genes?
?normally?repressed?by?chromatin. | ?≥95% |
| ?11289 | ?BRM?bromodomain?(human?
?recombinant) | ?BRM?is?a?member?of?the?SWI/SNF?proteins?
?family,?which?forms?part?of?the?large?ATP-
?dependent?chromatin?remodeling?complex?that?
?is?requires?for?transciptional?activation?of?genes?
?normally?repressed?by?chromatin. | ?≥95% |
| ?11650 | ?BRPF3?bromodomain?1?(human?
?recombinant) | ?BRPF3?is?a?component?of?the?MOZ/MORF?
?histone?acetytransferase(HAT)?complex.The?
?addition?of?BRPF?proteins?to?MOZ/MORF?
?increases?its?HAT?activity.This?product?contains?
?the?first?bromodomain?of?BRPF3. | ?≥95% |
| ?14133 | ?CECR2?bromodomain?(human?
?recombinant) | ?CECR2?is?a?transcription?factor?that?forms?a?
?heterodimeric?complex?with?the?ATP-dependent?
?chromation?remodeler?SNF2L?forming?the?
?CERF，?which?plays?a?critical?role?in?neurula-
?tion.?The?bromodomain?of?CECR2?has?strong?
?γ-H2AX?inhibition?activity?suggesting?that?CEC-
?R2?may?play?a?role?in?DNA?damage?response. | ?≥95% |
| 11288 | ?CREB-binding?protein?bromodomain?(human?
?recombinant) | ?The?CREBBP?bromodomain?has?been?shown?
?to?modulate?the?stability?and?function?of?the?
?tumor?suppressor?protein?p53.?CREBBP?brom-
?odomain?recognizes?the?acetylated?lysine?
?residue?382?on?p53. | ?≥95% |
| 11920 | ?PCAF?bromodomain?(human?recombinant) | ?p300/CBP-associated?factor(PCAF)?is?a?tran-
?scriptional?coactivator?that?works?both?as?a?
?histone?lysine?acetytransferase,?through?its?
?HAT?domain,?and?as?an?acety-lysine?reader?
?throung?its?conserved?bromodomain?located?
?directly?C-terminal?to?the?HAT?domain.The?
?PCAF?bromodomain?binds?acetylated?histone?
?H3?and?H4?as?well?as?non-histone?targets. | ?≥95% |
| 11652 | ?Polybromo-1D?bromodomain?1?(human?
?recombinant) | ?PBRM1?contains?six?bromodomains?and?is?a?
?component?of?the?SWI/SNF?complex,?PBAF.?
?PBAF?is?target?to?acetylated?sites?in?chromatin?
?by?the?PBRM1?bromodomains,?where?it?plays?a?
?role?in?cell?cycle?regulation?and?tumor?
?suppression. | ?≥95% |
| 14659 | ?SP140?PHD?and?bromodomain?(human?
?recombinant) | ?The?C-terminal?PHD?and?bromodomain?
?regions?of?SP140?work?in?concert?to?bind?to?
?chromatin?and?regulate?gene?transcription.?
?Nuclear?bodies,?which?are?involved?in?the?
?pathogenesis?of?acute?promyelocytic?leukemia?
?and?viral?infection,?consist?of?several?
?components,such?as?Sp100,?NDP52,PML,?and?
?SP140. | ?≥95% |
| 11922 | ?TAF1?bromodomain?1?(human?recombinant) | ?TAF1?is?a?component?of?transcription?factor?IID,?
?and?binds?to?core?promoter?sequences?at?the?
?transcription?start?site.?TAF1?helps?control?
?transcription?by?both?its?kinase?and?histone?
?acetyltranferase?enzymatic?activities.?This?
?protein?product?contains?the?first?bromodomain?
?of?TAF1. | ?≥95% |
| 14495 | ?TAF1?bromodomain?2?(human?recombinant) | ?Contains?the?second?bromodomain?of?TAF1 | ?≥95% |
| 14494 | ?TAF1?bromodomains?1?and?2?(human?
?recombinant) | ?Contains?the?first?and?second?bromodomains?
?of?TAF1 | ?≥90% |
| 11653 | ?TRIM24?bromodomain?(human?recombinant)? | ?TRIM24?is?a?transcriptional?confactor?whose?
?inactivation?leads?to?hepatocellular?carcinoma?
?in?mice.?The?N-terminal?TRIM?domain?of?TRIM-
?24?binds?ligand-bound?nuclear?receptors,?while?
?its?tandem?C-terminal?plant?homeo-domain?
?and?bromodomain?target?TRIM24?to?acetylated?
?histones?in?chromatin. | ?≥95% |
| 14660 | ?TRIM28?PHD?and?bromodomain?(human?
?recombinant)? | ?TRIM28,?a??KRAB?associated?protein,?in-
?teracts?with?SETD1?and?other?methyltrans-
?ferases?for?gene?silencing?of?endogenous?
?retroviruses?during?embryogenesis.The?PHD?
?finger?of?TRIM28?plays?an?important?role?in ?
?gene?silencing.The?PHD?domain?and?bromo-
?domain?of?TRIM28?work?together?to?facilitate?
?lysine?SUMOylation,?which?is?a?requirement?
?for?TRIM28?activity?in?gene?silencing. | ?≥85% |
| 14661 | ?TRIM33?PHD?and?bromodomain?(human?
?recombinant)? | ?TRIM33?is?a?multi-domain?regulator?of?
?transcription?that?is?necessary?for?emb-
?ryogenesis.?TRIM33?is?targeted?to?DNA?by?
?its?tandem?PHD?and?bromodomain,?which?
?bind?histone?3?at?H3K9me3?and?
?H3K18ac,respectively. | ?≥80% |
| 11549 | ?WDR9?bromodomain?2?(human?recombinant) | ?WDR9?pessesses?two?bromodomain?
?motifs?and?eight?WD?repeats.It?is?also?
?known?to?interact?with?BRG1?(SMARCA4). | ?≥85% |