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TLR2激動劑(又名CD282)及相關(guān)產(chǎn)品介紹

2022-04-12
瀏覽次數(shù): 4378

TLR2(又名CD282)是一個可以識別多種微生物表面分子的細胞膜表面受體。它識別的分子可來源于革蘭氏陽性菌、革蘭氏陰性菌、支原體和酵母等許多微生物種屬。


TLR2識別的具體成份包括來源于革蘭氏陽性菌的肽聚糖、脂膜酸、脂蛋白,來源于分枝桿菌的脂阿拉伯甘露聚糖,來源于酵母細胞壁的酵母聚糖等。


TLR2識別的配體種類在TLR家族中是最多的,因為TLR2可以和其它TLR家族成員形成異源二聚體來發(fā)揮功能。


TLR2可以和TLR6形成異源二聚體識別雙?;鞍祝鳷LR1/TLR2異源二聚體則與三?;鞍装l(fā)生相互作用。


另外,CD14共受體的存在可增強TLR2的病原識別能力。TLR2信號通路的激活依賴于MyD88分子(骨髓來源的第一應(yīng)激蛋白88),進而招募接頭分子TIRAP(TIR相關(guān)蛋白),導(dǎo)致AP-1和NF-kB等轉(zhuǎn)錄因子入核來促進一些炎癥因子的釋放。


TLR2激動劑相關(guān)產(chǎn)品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR LIGANDS

TLR2 Agonists

CL401

PAM2C-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

1 ng - 10 μg/ml

500 μg

tlrl-c401

CL401 VacciGrade?

Preclinical grade CL401

VacciGrade?

20 - 50 μg/mouse

5 mg

vac-c401-5

CL413 - Adilipoline?

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

50 pg - 10 μg/ml

500 μg

tlrl-c413

CL413 VacciGrade?

Preclinical grade CL413

VacciGrade?

20 - 50 μg/mouse

5 mg

vac-c413-5

CL419

Pam2C-spermine compound

TLR2 +/ TLR4 -

1 ng - 100 μg/ml

500 μg

tlrl-c419

CL429

Pam2C-conjugated murabutide

TLR2 +/ TLR4 -

1 ng - 10 μg/ml

5 mg

tlrl-c429

CL429 VacciGrade?

Preclinical grade CL429

VacciGrade?

20 - 50 μg/mouse

5 mg

vac-c429

CL531

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

5 pg - 10 μg/ml

500 μg

tlrl-c531

CL572

Monoacyl-ethyl-cystein hydroxyadenine compound

TLR2 +/ TLR4 -

0.5 ng - 1 μg/ml

500 μg

tlrl-c572

FSL-1

Synthetic diacylated lipoprotein - TLR2/6

TLR2 +/ TLR4 -

1 - 100 ng/ml

100 μg

tlrl-fsl

HKBF

Heat Killed Bacteroides fragilis

TLR2 +/ TLR4 -

106 - 107 cells/m

109 cells

tlrl-hkbf

HKEB

Heat Killed Escherichia coli 0111:B4

TLR2 +/ TLR4 +

105 - 107 cells/ml

1010 cells

tlrl-hkeb

HKLM

Heat Killed Listeria monocytogenes

TLR2 +/ TLR4 -

107 - 108 cells/ml

1010 cells

tlrl-hklm

HKLR

Heat Killed Lactobacillus rhamnosus

TLR2 +/ TLR4 -

108 - 109 cells/ml

1010 cells

tlrl-hklr

HKMT

Heat Killed Mycobacterium tuberculosis

TLR2 +/ TLR4 -

100 ng - 10 μg/ml

10 mg

50 mg

tlrl-hkmt-1

tlrl-hkmt-5

HKPA

Heat Killed Pseudomonas aeruginosa

TLR2 +/ TLR4 -

105 - 107 cells/ml

1010 cells

tlrl-hkpa

HKSA

Heat Killed Staphylococcus aureus

TLR2 +/ TLR4 -

106 - 108 cells/ml

1010 cells

tlrl-hksa

HKSE

Heat Killed Staphylococcus epidermidis

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hkse

HKSP

Heat Killed Streptococcus pneumoniae

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hksp

HKST

Heat Killed Salmonella typhimurium

TLR2 +/ TLR4 +

104 - 109 cells/ml

1010 cells

tlrl-hkst

LPS-PG

Standard Lipopolysaccharide from P. gingivalis

TLR2 +/ TLR4 +

10 ng - 10 mg/ml

1 mg

tlrl-pglps

LTA-BS

Lipoteichoic acid from Bacillus subtilis

TLR2 +/ TLR4 +

100 ng - 1 μg/ml

5 mg

tlrl-lta

LTA-SA

Lipoteichoic acid from S. aureus

TLR2 +/ TLR4 +

100 ng - 1 μg/ml

5 mg

tlrl-slta

LTA-SA Purified

Purified lipoteichoic acid from S. aureus

TLR2 +/ TLR4 -

1 ng - 1 μg/ml

5 mg

tlrl-pslta

Pam2CSK4

Synthetic diacylated lipoprotein - TLR2(6)

TLR2 +/ TLR4 -

1 - 100 ng/ml

1 mg

tlrl-pm2s-1

Pam3CSK4

Synthetic triacylated lipoprotein - TLR1/2

TLR2 +/ TLR4 -

1 - 300 ng/ml

1 mg

tlrl-pms

Pam3CSK4 Biotin

Biotinylated Pam3CSK4

TLR2 +/ TLR4 -

10 - 300 ng/ml

50 μg

tlrl-bpms

Pam3CSK4 Rhodamine

Rhodamine-labeled Pam3CSK4

TLR2 +/ TLR4 -

1 - 300 ng/ml

50 μg

tlrl-rpms

Pam3CSK4 VacciGrade?

Preclinical grade Pam3CSK4

VacciGrade?

2 - 20 μg/mouse

1 mg

vac-pms

PGN-BS

Peptidoglycan from B. subtilis

TLR2 +/ TLR4 -

1 - 10 μg/ml

5 mg

tlrl-pgnb3

PGN-EB

Peptidoglycan from E. coli 0111:B4

TLR2 +/ TLR4 +

1 - 10 μg/ml

1 mg

tlrl-pgneb

PGN-EK

Peptidoglycan from E. coli K12

TLR2 +/ TLR4 +

1 - 10 μg/ml

1 mg

tlrl-pgnek

PGN-SA

Peptidoglycan from S. aureus

TLR2 +/ TLR4 -

0.1 - 10 μg/ml

5 mg

tlrl-pgns2

Zymosan

Cell wall preparation of S. cerevisiae

TLR2 +/ TLR4 -

1-10 μg/ml

100 mg

tlrl-zyn


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