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TLR4 激動劑及相關(guān)產(chǎn)品介紹

2022-04-12
瀏覽次數(shù): 562

TLR4是革蘭氏陰性菌脂多糖(LPS)和毒性成份lipid A的受體。TLR4與LPS的應(yīng)答,除了受體本身,也需要另外3種不同的胞外蛋白:LBP(LPS結(jié)合蛋白)、CD14和MD-2(髓樣分化蛋白2)才能發(fā)揮作用。TLR4介導(dǎo)的信號通路有兩條:一條是MyD88依賴 的,另一條是MyD88非依賴的。MyD88依賴的信號通路導(dǎo)致AP-1和NF-kB等轉(zhuǎn)錄因子入核,促進(jìn)一些炎癥因子的釋放;MyD88非依賴的信號通路可激活I(lǐng)RF3和另外一個(gè)接頭分子TRAM(TRIF相關(guān)的接頭蛋白),IRF3活化后可使細(xì)胞產(chǎn)生IFN-??,上調(diào)一些干擾素依賴基因的表達(dá)。


TLR4激動劑相關(guān)產(chǎn)品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR4 Agonists

CRX-527??????????? NEW?????????

Synthetic Lipid A analog

TLR2 - /TLR4 +

100 pg/ml - 10 ng/ml

1 mg

tlrl-crx527

LPS-B5

Standard lipopolysaccharide from E. coli 055:B5

TLR2 + /TLR4 +

100 pg - 1 μg/ml

5 mg

tlrl-b5lps

LPS-B5 Ultrapure

Ultrapure lipopolysaccharide from E. coli 055:B5

TLR2 - /TLR4 +

100 pg - 1 μg/ml

5 mg

tlrl-pb5lps

LPS-EB

Standard lipopolysaccharide from E. coli 0111:B4

TLR2 + /TLR4 +

10 ng - 10 μg/ml

5 mg

tlrl-eblps

LPS-EB Biotin

Biotinylated ultrapure LPS from E. coli 0111:B4

TLR2 + /TLR4 +

10 ng - 10 μg/ml

500 μg

tlrl-3blps

LPS-EB Ultrapure

Ultrapure lipopolysaccharide from E. coli 0111:B4

TLR2 - /TLR4 +

10 ng - 10 μg/ml

5x106 EU

tlrl-3pelps

LPS-EB VacciGrade?

Preclinical grade ultrapure LPS from E. coli 0111:B4

VacciGrade?

0.1 - 25 μg/mouse

5x106 EU

vac-3pelps

LPS-EK

Standard lipopolysaccharide from E. coli K12

TLR2 + /TLR4 +

1 ng - 10 μg/ml

5 mg

tlrl-eklps

LPS-EK Ultrapure

Ultrapure lipopolysaccharide from E. coli K12

TLR2 - /TLR4 +

1 ng - 10 μg/ml

1 mg

tlrl-peklps

LPS-PG

Standard lipopolysaccharide from P. gingivalis

TLR2 + /TLR4 +

100 ng - 10 μg/ml

1 mg

tlrl-pglps

LPS-PG Ultrapure

Ultrapure lipopolysaccharide from P. gingivalis

TLR2 - /TLR4 +

100 ng - 10 μg/ml

1 mg

tlrl-ppglps

LPS-SM Ultrapure

Ultrapure lipopolysaccharide from S. minnesota

TLR2 - /TLR4 +

10 ng - 10 μg/ml

5 mg

tlrl-smlps

MPLA-SM

Monophosphoryl lipid A from S. minnesota

TLR2 - /TLR4 +

10 ng - 1 μg/ml

1 mg

tlrl-mpla

MPLA-SM VacciGrade?

Preclinical grade detoxified MPLA

VacciGrade?

2 - 20 μg/mouse

1 mg

vac-mpla

MPLA Synthetic

Synthetic monophosphoryl lipid A

TLR2 - /TLR4 +

300 pg - 100 ng/ml

1 mg

tlrl-mpls

MPLA Synthetic VacciGrade?

Preclinical grade synthetic MPLA

VacciGrade?

2 - 20 μg/mouse

1 mg

vac-mpls

TLR4 Antagonist

LPS-RS

Lipopolysaccharide from Rhodobacter sphaeroides

TLR2 + /TLR4 -

10 ng - 10 μg/ml

5 mg

tlrl-rslps

LPS-RS Ultrapure

Ultrapure lipopolysaccharide from R. sphaeroides

TLR2 - /TLR4 -

10 ng - 10 μg/ml

1 mg

tlrl-prslps


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