NOD1(又稱(chēng)CARD4)和NOD2(又稱(chēng)CARD15)是能感知細(xì)菌肽聚糖(PGN)成份的細(xì)胞內(nèi)模式識(shí)別受體。NOD1識(shí)別全部革蘭氏陰性菌和部分革蘭氏陽(yáng)性菌PGN成份中的iE-DAP，而NOD2則識(shí)別差不多全部細(xì)菌都帶有的MDP結(jié)構(gòu)。iE-DAP和MDP成份必須通過(guò)細(xì)菌侵入細(xì)胞或其它細(xì)胞物質(zhì)攝入方式進(jìn)入到細(xì)胞后才能被識(shí)別。識(shí)別配體后，NOD1和NOD2形成多聚體，通過(guò)RIP2激酶的絲氨酸/酪氨酸來(lái)傳遞訊號(hào)。激活后的RIP2可泛素化修飾NEMO/IKK?，從而引起NF-kB的活化和炎癥因子的釋放。
NOD1/2激動(dòng)劑相關(guān)產(chǎn)品：
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
NOD1 Agonists |
C12-iE-DAP | Acylated derivative of iE-DAP | TLR2 -/ TLR4 - | 1 ng - 1 μg/ml | 1 mg | tlrl-c12dap |
C14-Tri-LAN-Gly???????????????? NEW | Meso?lanthionine tri-peptide (CL243) | TLR2 -/ TLR4 - | 1 ng - 1 μg/ml | 1 mg | tlrl-ctlg |
iE-DAP | D-γ-Glu-mDAP | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 5 mg | tlrl-dap |
iE-Lys | iE-DAP negative control | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 5 mg | tlrl-lys |
Tri-DAP | L-Ala-γ-D-Glu-mDAP | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 1 mg | tlrl-tdap |
NOD2 Agonists |
CL429 | Pam2C-conjugated murabutide | TLR2 +/ TLR4 - | 1 ng - 10 μg/ml | 5 mg | tlrl-c429 |
CL429 VacciGrade? | TLR2/NOD2 agonist | VacciGrade? | 20 -50 μg/mouse | 5 mg | vac-c429 |
L18-MDP | Muramyldipeptide with a C18 fatty acid chain | TLR2 -/ TLR4 - | 1 - 100 ng/ml | 1 mg | tlrl-lmdp |
MDP | Muramyldipeptide (L-D isoform, active) | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 5 mg | tlrl-mdp |
MDP control | Muramyldipeptide (D-D isoform, inactive) | TLR2 -/ TLR4 - | 10 ng - 10 μg/ml | 5 mg | tlrl-mdpc |
M-TriLYS | Synthetic muramyl tripeptide | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 1 mg | tlrl-mtl |
Murabutide | Synthetic derivative of muramyldipeptide | TLR2 -/ TLR4 - | 1 - 100 ng/ml | 5 mg | tlrl-mbt |
N-Glycolyl-MDP | N-glycolylated muramyldipeptide | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 5 mg | tlrl-gmdp |
NOD1/2 Agonists |
M-TriDAP | MurNAc-L-Ala-γ-D-Glu-mDAP | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 1 mg | tlrl-mtd |
PGN-ECndi Ultrapure | Insoluble peptidoglycan from E. coli K12 | TLR2 -/ TLR4 - | 1 - 5 μg/ml | 5 mg | tlrl-kipgn |
PGN-ECndss Ultrapure | Soluble sonicated peptidoglycan from E. coli K12 | TLR2 -/ TLR4 - | 1 - 5 μg/ml | 1 mg | tlrl-ksspgn |
PGN-SAndi Ultrapure | Insoluble peptidoglycan from S. aureus | TLR2 -/ TLR4 - | 1 - 5 μg/ml | 5 mg | tlrl-sipgn |
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