STING分子在最初發(fā)現(xiàn)時只被認為是CDS信號通路中的一個普通接頭蛋白，進一步研究表明它是環(huán)二核苷酸cyclic dinucleotide(CDNs)的直接感受分子。CDNs是細菌合成的重要第二信使，調(diào)節(jié)原核生物及哺乳動物的眾多生物進程，能啟動宿主天然免疫反應。CDNs和山酮衍生物xanthenone derivative(例如DMXAA)，可結(jié)合并活化STING，通過TBK1-IRF3依賴的信號通路來誘導I型干擾素表達。
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PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
STING Agonists |
2’2’-cGAMP | 2’5’-2’5’ Cyclic GMP-AMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 500 μg 1 mg | tlrl-nacga22 tlrl-nacga22-1 |
2’3’-cGAMP | 2’5’-3’5’ Cyclic GMP-AMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 200 μg 500 μg 1 mg 5 mg | tlrl-ncga23-02 tlrl-nacga23 tlrl-nacga23-1 tlrl-nacga23-5 |
2’3’-cGAMP Control | Linear dinucleotide analog of 2’3’-cGAMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 1 mg | tlrl-nagpap |
2’3’-cGAMP VacciGrade??? | Preclinical grade 2’5’-3’5’ cyclic GMP-AMP | VacciGrade? | 5 - 50 μg/mouse | 1 mg | vac-nacga23 |
2’3’-cGAM(PS)2 (Rp/Sp) | Bis-phosphorothioate analog of 2’3’-cGAMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 250 μg | tlrl-nacga2srs |
2’3’-c-di-AMP | Synthetic analog of? c-di-AMP | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 500 μg | tlrl-nacda23 |
2’3’-c-di-AM(PS)2 (Rp,Rp) | Bisphosphorothioate analog of 2’3’-c-di-AMP | TLR2 -/ TLR4 - | 0.1-10 μg/ml | 100 μg 500 μg | tlrl-nada2r-01 tlrl-nacda2r |
2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade? | Preclinical grade of bisphosphorothioate analog of
2’3’-c-di-AMP | VacciGrade? | 5-50 μg/mouse | 500 μg | vac-nacda2r |
2’3’-c-di-GMP | Synthetic analog of c-di-GMP | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 500 μg | tlrl-nacdg23 |
3’3’-cGAMP | 3’5’-3’5’ Cyclic GMP-AMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 500 μg 1 mg 5 x 0.5 mg | tlrl-nacga tlrl-nacga-1 tlrl-nacga-2.5 |
3’3’-cGAMP Control | Linear dinucleotide analog of 3’3’-cGAMP | TLR2 -/ TLR4 - | 100 ng - 100 μg/ml | 1 mg | tlrl-nagpap |
3’3’-cGAMP Fluorinated | Difluor cyclic [G(3’,5’)pA(3’,5’)p] | TLR2 -/ TLR4 - | 100 ng - 10 μg/ml | 100 μg | tlrl-nacgaf |
cAIMP (CL592) | Cyclic [A(3’,5’)pI(3’,5’)p] | TLR2 -/ TLR4 - | 300 ng - 30 μg/ml | 500 μg | tlrl-nacai |
cAIMP Difluor (CL614) | Difluor cyclic [A(3’,5’)pI(3’,5’)p] | TLR2 -/ TLR4 - | 100 ng - 30 μg/ml | 250 μg | tlrl-nacaidf |
cAIM(PS)2 Difluor (Rp/Sp) | Difluor and bisphosphorothioate analog of cAIMP | TLR2 -/ TLR4 - | 100 ng - 30 μg/ml | 100 μg | tlrl-nacairs |
c-di-AMP | 3’5’ Cyclic di-AMP | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 1 mg 5 x 1 mg | tlrl-nacda tlrl-nacda-5 |
c-di-AMP Control | Linear dinucleotide analog of c-di-AMP - pApA | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 1 mg | tlrl-napapa |
c-di-AMP VacciGrade? | Sterile 3’5’ cyclic di-AMP | VacciGrade? | 5 - 50 μg/mouse | 1 mg | vac-nacda |
c-di-AMP Fluorinated | Difluoro [A(3’,5’)pA(3’,5’)p] | TLR2 -/ TLR4 - | 300 ng - 30 μg/ml | 100 μg | tlrl-nacdaf |
c-di-GMP | 3’5’ Cyclic di-GMP | TLR2 -/ TLR4 - | 10 - 100 μg/ml | 1 mg 5 x 1 mg | tlrl-nacdg tlrl-nacdg-5 |
c-di-GMP Control | Linear dinucleotide 5’-pGpG; negative control for c-di-GMP | TLR2 -/ TLR4 - | 10 - 100 μg/ml | 1 mg | tlrl-napgpg |
c-di-GMP VacciGrade? | Preclinical grade of cyclic [G(3’,5’)pG(3’,5’)p] | VacciGrade? | 5 - 50 μg/mouse | 1 mg | tlrl-nacdg |
c-di-GMP Fluorinated | Difluoro cyclic [G(3’,5’)pG(3’,5’)p] | TLR2 -/ TLR4 - | 3 - 100 μg/ml | 100 μg | tlrl-nacdgf |
c-di-IMP | Cyclic [I(3’,5’)pI(3’,5’)p] | TLR2 -/ TLR4 - | 10 - 100 μg/ml | 1 mg | tlrl-nacdi |
c-di-UMP | Negative control for c-di-IMP | TLR2 -/ TLR4 - | 1 - 100 μg/ml | 1 mg | tlrl-nacdu |
DMXAA | 5,6-dimethyl-xanthenone-4-acetic acid | TLR2 -/ TLR4 - | 10 - 100 μg/ml | 5 mg | tlrl-dmx |
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