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轉(zhuǎn)錄因子報(bào)告基因細(xì)胞(人源和鼠源細(xì)胞系)

2023-02-22
瀏覽次數(shù): 80

InvivoGen提供一系列人源和鼠源細(xì)胞系以供研究由PRR配體或細(xì)胞因子激發(fā)的信號級聯(lián)反應(yīng)中蛋白質(zhì)發(fā)揮的作用。

在具有NF-κB, IRFs, NFAT, 或AhR轉(zhuǎn)錄因子元件的啟動(dòng)子的控制下,這些細(xì)胞均可以表達(dá)SEAP分泌型堿性磷酸酶或Lucia熒光素酶報(bào)告基因。

部分細(xì)胞系會(huì)敲除特定表達(dá)基因以達(dá)到篩選的目的。

所有細(xì)胞系均通過不同方法進(jìn)行嚴(yán)格的生物活性檢測(PCR, DNA測序,Western- Blot, FACS以及功能驗(yàn)證)。


轉(zhuǎn)錄因子報(bào)告基因細(xì)胞(人源)

細(xì)胞系產(chǎn)品名稱通路概述報(bào)告系統(tǒng)*貨號
HUMAN REPORTER CELLS
A549A549-Dual?NF-κB & IRFsSEAP / Luciaa549d-nfis
HCT116HCT116-Dual?NF-κB & IRFsSEAP / Luciahctd-nfis
HEK293HEK-Blue? ISGIRFsSEAPhkb-isg
293-Dual? NullDouble readout** (IRFs/ IFN-β), Lucia knocked into IFN-βSEAP / Lucia293d-null
HEK-Dual? NullDouble readout** (NF-κB / IL-8), Lucia knocked into IL-8SEAP / Luciahkd-nullni
HepG2HepG2-Dual?NF-κB & IRFsSEAP / Luciahepg2d-nfis
HepG2-Lucia? AhRAhRLuciahpgl-ahr
HT29HT29-Lucia? AhRAhRLuciaht2l-ahr
JurkatJurkat-Dual?NF-κB & IRFsLucia / SEAPjktd-isnf
Jurkat-Lucia? NFATNFATLuciajktl-nfat
Jurkat-Lucia? NFAT-CD16NFAT, human CD16A (FcγRIIIA, V158 allotype) transfectedLuciajktl-nfat-cd16
RamosRamos-Blue?NF-κB / AP-1SEAPrms-sp
Ramos-Blue? KD-MyDNF-κB / AP-1, knockdown of human MyD88SEAPrms-kdmyd
THP-1THP1-Blue? NF-κBNF-κBSEAPthp-nfkb
THP1-Lucia? NF-κBNF-κBLuciathpl-nfkb
THP1-Blue?-ISGIRFsSEAPthp-isg
THP1-Lucia? ISGIRFsLuciathpl-isg
THP1-Dual?NF-κB & IRFsSEAP / Luciathpd-nfis
THP1-Dual? KO-IRF1NF-κB & IRFs, knockout of human IRF1SEAP / Luciathpd-koirf1
THP1-Dual? KO IRF3NF-κB & IRFs, knockout of human IRF3SEAP / Luciathpd-koirf3
THP1-Dual? KO IRF5NF-κB & IRFs, knockout of human IRF5SEAP / Luciathpd-koirf5
THP1-Dual? KO IRF7NF-κB & IRFs, knockout of human IRF7SEAP / Luciathpd-koirf7


轉(zhuǎn)錄因子報(bào)告基因細(xì)胞(鼠源)

細(xì)胞系產(chǎn)品名稱通路概述報(bào)告系統(tǒng)*貨號
MOUSE REPORTER CELLS
B16B16-Blue? ISGIRFsSEAPbb-ifnabg
J774J774-Dual?NF-κB & IRFsSEAP / Luciaj774d-nfis
RAWRAW-Blue?NF-κB / AP-1SEAPraw-sp
RAW-Dual?IRFs & MIP-2 (NF-κB)SEAP / Luciarawd-ismip
RAW-Lucia? ISGIRFsLuciarawl-isg
RAW-Lucia? ISG-KO-IRF1IRFs, knockout of mouse IRF1Luciarawl-koirf1
RAW-Lucia? ISG-KO-IRF3IRFs, knockout of mouse IRF3Luciarawl-koirf3
RAW-Lucia? ISG-KO-IRF5IRFs, knockout of mouse IRF5Luciarawl-koirf5
RAW-Lucia? ISG-KO-IRF7IRFs, knockout of mouse IRF7Luciarawl-koirf7


轉(zhuǎn)錄因子報(bào)告基因細(xì)胞

關(guān)鍵信號基因敲除細(xì)胞(人源和鼠源)

細(xì)胞系產(chǎn)品名稱通路概述報(bào)告系統(tǒng)*貨號
HUMAN REPORTER CELLS
THP1THP1-Dual? KO-IFNAR2NF-κB & IRFs, knockout of human IFNAR2SEAP / Luciathpd-koifnar2
THP1-Dual? KO-IKK?NF-κB & IRFs, knockout of human IKK?SEAP / Luciathpd-koikke
THP1-Dual? KO-MyDNF-κB & IRFs, knockout of human MyD88SEAP / Luciathpd-komyd
THP1-Dual? KO-TBK1NF-κB & IRFs, knockout of human TBK1SEAP / Luciathpd-kotbk
THP1-Dual? KO-TREX1NF-κB & IRFs, knockout of human TREX1SEAP / Luciathpd-kotrex
THP1-Dual? KO-TRIFNF-κB & IRFs, knockout of human TRIFSEAP / Luciathpd-kotrif
MOUSE REPORTER CELLS
RAWRAW-Lucia? ISG-KO-TBK1IRFs, knockout of mouse TBK1Luciarawl-kotbk
RAW-Lucia? ISG-KO-TREX1IRFs, knockout of mouse TREX1Luciarawl-kotrex
RAW-Lucia? ISG-KO-TRIFIRFs, knockout of mouse TRIFLuciarawl-kotrif

*當(dāng)有兩個(gè)報(bào)告蛋白表示時(shí),第一個(gè)蛋白對應(yīng)第一條通路,第二個(gè)對應(yīng)第二條通路。

**雙重讀數(shù)表明在該通路中,當(dāng)?shù)诙€(gè)報(bào)告基因敲入后,轉(zhuǎn)錄因子被激活且指示基因被表達(dá)。因此該通路可以使用任何一個(gè)報(bào)告檢測系統(tǒng)。


目前Invivogen的細(xì)胞系產(chǎn)品在不斷地?cái)U(kuò)展,母源細(xì)胞系和對照細(xì)胞系均可提供!



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