細(xì)胞因子與免疫系統(tǒng)細(xì)胞相互作用可調(diào)節(jié)宿主對(duì)于疾病和感染的反應(yīng)，并介導(dǎo)正常的細(xì)胞過(guò)程。InvivoGen提供針對(duì)不同細(xì)胞因子（干擾素、白細(xì)胞介素、TNF和TGF）信號(hào)通路的報(bào)告基因細(xì)胞。所有細(xì)胞系的生物活性均經(jīng)過(guò)嚴(yán)格的功能測(cè)試分析。另外，InvivoGen也提供一系列細(xì)胞因子報(bào)告基因細(xì)胞，可用于研究在更多嚴(yán)重感染病例中，如SARS-CoV-2引發(fā)的高度炎癥反應(yīng)的通路。
| 細(xì)胞系 | 產(chǎn)品名稱(chēng) | 表達(dá)系統(tǒng) | 報(bào)告系統(tǒng) | 貨號(hào) |
| INTERFERONREPORTERCELLS |
| B16(mouse) | B16-Blue?IFN-α/β | MousetypeIIFNs(JAK/ISGF3pathway) | SEAP | bb-ifnt1 |
| B16-Blue?IFN-γ | MousetypeIIIFN(JAK/STAT-1pathway) | SEAP | bb-ifng |
| HEK293(human) | HEK-Blue?IFN-α/β | HumantypeIIFNs(JAK/ISGF3pathway) | SEAP | hkb-ifnab |
| HEK-Blue?IFN-γ | HumantypeIIIFN(JAK/STAT-1pathway) | SEAP | hkb-ifng |
| HEK-Blue?IFN-λ | HumantypeIIIIFN(JAK/ISGF3pathway) | SEAP | hkb-ifnl |
| HEK-Dual?IFN-γ | HumantypeIIIFN(JAK/STAT-1pathway) | SEAP/Lucia | hkd-ifng |
| INTERLEUKINREPORTERCELLS |
| HEK293?(human) | HEK-Blue?IL-1β | Human&mouseIL-1β(NF-κB/AP-1pathway) | SEAP | hkb-il1b |
| HEK-Blue?IL-1R | Human&mouseIL-1α/β(NF-κB/AP-1pathway) | SEAP | hkb-il1r |
| HEK-Blue?IL-2 | Human&mouseIL-2(STAT-5pathway) | SEAP | hkb-il2 |
| HEK-Blue?CD122/CD132 | HumanIL-2&IL-15(STAT-5pathway) | SEAP | hkb-il2bg |
| HEK-Blue?IL-4/IL-13 | HumanIL-4andhuman&mouseIL-13(STAT-6pathway) | SEAP | hkb-il413 |
| HEK-Blue?IL-5 | Human&mouseIL-5(STAT-5pathway) | SEAP | hkb-il5 |
| HEK-Blue?IL-6 | HumanIL-6(STAT-3pathway) | SEAP | hkb-hil6 |
| HEK-Blue?IL-7 | Human&mouseIL-7(STAT-5pathway) | SEAP | hkb-il7 |
| HEK-Blue?IL-9 | Human&mouseIL-9(STAT-5pathway) | SEAP | hkb-il9 |
| HEK-Blue?IL-10 | HumanIL-10(STAT-3pathway) | SEAP | hkb-hil10 |
| HEK-Blue?IL-11 | Human&mouseIL-11(STAT-3pathway) | SEAP | hkb-il11 |
| HEK-Blue?IL-12 | Human&mouseIL-12(STAT-4pathway) | SEAP | hkb-il12 |
| HEK-Blue?IL-17 | HumanIL-17A/Fandhuman&mouseIL-17E(NF-κB/AP-1pathway) | SEAP | hkb-il17 |
| HEK-Blue?IL-17C | Human&mouseIL-17C/EandhumanIL-17A(NF-κB/AP-1pathway) | SEAP | hkb-il17c |
| HEK-Blue?IL-18 | Human&mouseIL-18(NF-κB/AP-1pathway) | SEAP | hkb-hmil18 |
| HEK-Blue?IL-22 | Human&mouseIL-22(STAT-3pathway) | SEAP | hkb-hmil22 |
| HEK-Blue?IL-23 | Human&mouseIL-23(STAT-3pathway) | SEAP | hkb-hmil23 |
| HEK-Blue?IL-33 | HumanIL-33reportercells(NF-κB/AP-1pathway) | SEAP | hkb-hil33 |
| HEK-Blue?IL-36 | HumanIL-36reportercells(NF-κB/AP-1pathway) | SEAP | hkb-hil36 |
| TUMORNECROSISFACTORFAMILYCYTOKINES&TUMORGROWTHFACTORREPORTERCELLS |
| HEK293?(human) | HEK-Blue?CD40L | HumanCD40L(NF-κBpathway) | SEAP | hkb-cd40 |
| HEK-Blue?RANKL | Human&mouseRANKL(NF-κB/AP-1pathway) | SEAP | hkb-rankl |
| HEK-Blue?TNF-α | Human&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88 | SEAP | hkb-tnfdmyd |
| HEK-Dual?TNF-α | Human&mouseTNF-α(NF-κB/AP-1pathway),knockdownofhumanMyD88 | SEAP/Lucia | hkd-tnfa |
| HEK-Blue?TGF-β | HumanTGF-β(TGFBRI/Smad3/4pathway) | SEAP | hkb-tgfb |
| HEK-Blue?TPO | Human&mouseTPO(STAT5pathway) |
|
|
| CHEMOKINETESTCELLS |
| THP-1(human) | THP1-Blue?KI-IP10 | LuciaknockedintohumanIP10(CXCL10)(parentalcelllineTHP1-Blue?NF-κB) | SEAP/Lucia | thpb-ip10kilc |
使用INVIVOGEN細(xì)胞因子效應(yīng)器細(xì)胞的優(yōu)點(diǎn)
細(xì)胞因子生物活性的檢測(cè) ?
高靈敏度
成本效益 ?
廣泛的動(dòng)態(tài)范圍
短暫動(dòng)手實(shí)驗(yàn)
裸眼視覺(jué)化
適用于藥物篩選（普通篩選或高通量篩選，動(dòng)力學(xué)）
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