瘦素(Leptin)是由ob基因編碼、在脂肪組織中生成的一種脂肪代謝調(diào)控產(chǎn)物，在代謝和調(diào)控體重等方面發(fā)揮重要作用。它通過(guò)下丘腦中的瘦素受體發(fā)出信號(hào)，降低食欲，增加能量消耗。在外周組織中，瘦素能拮抗胰島素信號(hào)傳導(dǎo)，增加脂肪酸氧化，減少胰島β細(xì)胞的胰島素分泌，并促進(jìn)生育。它在脂肪細(xì)胞中的表達(dá)可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式調(diào)節(jié)。瘦素缺乏的小鼠表現(xiàn)出嚴(yán)重的胰島素抵抗、肥胖和生育能力下降，所有這些都可以通過(guò)外源性瘦素給藥而逆轉(zhuǎn)。
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●?靈敏：精確定量，可檢測(cè)到最低23.4 pg/mL瘦素
●?方便：所有試劑保存在4°C
●?快速：僅需3小時(shí)就可獲得39個(gè)樣本的重復(fù)結(jié)果
●?預(yù)包被板和即用型試劑為您節(jié)省實(shí)驗(yàn)時(shí)間
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產(chǎn)品信息
| 產(chǎn)品貨號(hào) | ADI-900-028A |
產(chǎn)品名稱 | Leptin (human), ELISA kit（人瘦素ELISA試劑盒） |
規(guī)格 | 96 wells |
靈敏度 | 23.4 pg/ml |
檢測(cè)范圍 | 31.3 - 2,000 pg/ml |
檢測(cè)時(shí)間 | 3 hours |
樣本種屬 | Human |
樣本類型 | culture supernatants, plasma, and serum |
保存溫度 | +4°C |
試劑盒組分 | Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 17, TMB Substrate, Stop solution 2, Wash buffer concentrate |
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部分產(chǎn)品引用文獻(xiàn)
1. Leptin favors Th17/Treg cell subsets imbalance associated with allergic asthma severity: C.M. Vollmer, et al.; Clin. Transl. Allergy 12, e12153 (2022)?
2. Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques: R. Rehman, et al.; Pak. J. Med. Sci. 34, 342 (2018), Application(s): ELISA using human serum?
3. Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): B. Almeida-Pititto, et al.; Diabetol. Metab. Syndr. 10, 82 (2018)
4. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus: G. Derosa, et al.; Hypertens. Res. 38, 690 (2015), Application(s): ELISA?
5. Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension: M. Tellechea, et al.; Sci. Rep. 5, 7869 (2015), Application(s): ELISA
6. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population: E. Chavarria-Avila, et al.; BioMed Res. Int. 2015, 539408 (2015), Application(s): ELISA using human serum
7.Association between obesity-related adipokines and colorectal cancer: A case-control study and meta-analysis: R. K. Joshi, et al.; World J. Gastroenterol. 20, 7941 (2014)
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