組胺是由氨基酸組氨酸合成的內(nèi)源性短效生物胺，廣泛分布于全身。組胺是速發(fā)型過(guò)敏反應(yīng)的一種重要介質(zhì)。正常情況下，人體內(nèi)僅存在少量的組胺。當(dāng)一種物質(zhì)進(jìn)入人體時(shí)（比如食物、化學(xué)品、昆蟲(chóng)叮咬、植物油脂），可能會(huì)引發(fā)過(guò)敏反應(yīng)。作為對(duì)該分子的反應(yīng)，身體就會(huì)釋放更大量的組胺并開(kāi)始免疫反應(yīng)。身體通過(guò)產(chǎn)生腎上腺素（腎上腺素）來(lái)平衡組胺的釋放，這可以幫助調(diào)節(jié)組胺的影響。由于組胺在免疫應(yīng)答中的強(qiáng)有力作用，組胺在體內(nèi)存在的時(shí)間很短暫，只能在釋放后幾分鐘內(nèi)測(cè)定。組胺也是一類(lèi)小分子神經(jīng)遞質(zhì)，這類(lèi)物質(zhì)包括5-羥色胺，腎上腺素和多巴胺等。此外，組胺在胃酸分泌中起作用，有助于誘導(dǎo)胃酸的產(chǎn)生。
ENZO Histamine ELISA kit是一種比色競(jìng)爭(zhēng)法免疫測(cè)定試劑盒，可在2.5小時(shí)內(nèi)得到檢測(cè)結(jié)果。
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?● 高靈敏度，可檢測(cè)低至0.03 ng / mL Histamine
?● 獨(dú)特的檢測(cè)方法，不需要額外的酰化步驟
?● 檢測(cè)范圍寬，適用于各種類(lèi)型樣品
?●?高通量，可檢測(cè)多達(dá)40個(gè)樣品（帶復(fù)孔），2.5可獲得結(jié)果
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產(chǎn)品信息
產(chǎn)品貨號(hào) | ENZ-KIT140A-0001 |
產(chǎn)品名稱(chēng) | Histamine ELISA kit（組胺ELISA試劑盒） |
規(guī)格 | 96 wells |
靈敏度 | 0.068 pg/ml |
檢測(cè)范圍 | 0.098-25 pg/ml |
檢測(cè)時(shí)間 | 2.5 hours |
樣本種屬 | Human, Mouse, Rat |
樣本類(lèi)型 | tissue culture media, serum, plasma and urine in human, mouse, and rat (serum only) samples |
保存溫度 | Store all components at +4°C, except conjugate, antibody, and tracer, which are stored at -20°C |
試劑盒組分 | Microtiter Plate, Assay Buffer 13, Standard, Wash Buffer Concentrate, Antibody, Tracer, Conjugate, Substrate, and Stop Solution |
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部分產(chǎn)品文獻(xiàn)引用
1. The allergy mediator histamine confers resistanceto immunotherapy in cancer patients via activationof the macrophage histamine receptor H1: H. Li, et al.; Cancer Cell 40, 36 (2022)
2. Angelica gigas extract ameliorates allergic rhinitis in an ovalbumin-induced mouse model by inhibiting Th2 cell activation: K.Y. Ji, et al.; Phytomedicine 93, 153789 (2021)
3. Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model: S. Choi, et al.; Biomed. Pharmacother. 141, 111944 (2021)
4. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis: R.D. Shelby, et al.; J. Pediatr. Surg. 22, 3468 (2021)
5. Rab44 isoforms similarly promote lysosomal exocytosis, but exhibit differential localization in mast cells: T. Kadowaki, et al.; FEBS Open Bio. 11, 1165 (2021), Application(s): Cell culture supernatant, BMMCs and RBL‐2H3?
6. Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells: S. Pal, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 318, R590 (2020), Application(s): Histamine concentration in lysates from rat mesenteric perilymphatic tissue
7. A connective tissue mast-cell-specific receptor detects bacterial quorum-sensing molecules and mediates antibacterial immunity: P. Pundir, et al.; Cell. Host. Microb. 26, 114 (2019), Application(s): Analysis of culture supernatants?
8. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology: H. Chen, et al.; Cell 177, 1217 (2019), Application(s): Quantification of histamine production by 144 isolates of human gut bacteria
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