血清素（5-羥色胺，5-HT）是一種存在于中樞神經(jīng)系統(tǒng)、胃腸道和血液中的單胺，在神經(jīng)傳遞、胃腸運(yùn)動(dòng)、止血和心血管完整性方面具有廣泛的生理功能?，F(xiàn)已發(fā)現(xiàn)七個(gè)亞類(lèi)（5-HT 1-7）的5-羥色胺受體，其中大部分是含有七個(gè)跨膜結(jié)構(gòu)域的GPCR家族成員，并且是幾種抗抑郁藥物的靶點(diǎn)。5-HT1亞類(lèi)由五個(gè)高度同源的受體組成，通過(guò)G(i/o) alpha亞基偶聯(lián)以抑制腺苷酸環(huán)化酶活性。5-HT1A在哺乳動(dòng)物中的表達(dá)在控制情緒的中樞神經(jīng)邊緣通路中最強(qiáng)，包括海馬體、背脊和隔膜的組織。血清素是用于監(jiān)測(cè)各種物種的健康狀況或評(píng)估行為障礙的關(guān)鍵生物標(biāo)志物。
ENZO Serotonin ELISA kit是一種比色競(jìng)爭(zhēng)法酶免疫檢測(cè)試劑盒，可在3小時(shí)內(nèi)得出結(jié)果。
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w?高靈敏度，可檢測(cè)低至0.293 ng/ml的血清素
w?標(biāo)準(zhǔn)品和樣品不需要酰化
w?已在多種樣本類(lèi)型中得到驗(yàn)證
w?高通量，3小時(shí)內(nèi)可得到結(jié)果，可檢測(cè)多達(dá)39個(gè)樣本（復(fù)孔）
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產(chǎn)品信息
產(chǎn)品貨號(hào) | ADI-900-175 |
產(chǎn)品名稱(chēng) | Serotonin ELISA kit（血清素ELISA試劑盒） |
規(guī)格 | 96 wells |
其他名稱(chēng) | 5-HT, 5-hydroxytryptamine |
靈敏度 | 0.293 ng/ml |
檢測(cè)范圍 | 0.49 - 500 ng/ml |
檢測(cè)時(shí)間 | 3 hours |
樣本種屬 | Species independent |
樣本類(lèi)型 | platelets, plasma, serum, and urine. Cited sample type includes culture supernatant. |
保存溫度 | Store all components at -20°C |
試劑盒組分 | GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution |
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部分產(chǎn)品引用文獻(xiàn)
1. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome: Z.A. Barandouzi, et al.; Sci. Rep. 12, 1648 (2022)
2. Enhanced presence of serotonin in nasal cavity after autologous stimulation: F. Salvinelli, et al.; Eur. Rev. Med. Pharmacol. Sci. 256, 2970 (2022)
3. Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields: E.D.D. Cerro, et al.; Environ. Health 21, 72 (2022)
4, Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management: M. Elbadawi, et al.; Pharmaceuticals (Basel) 15, 1121 (2022)
5. Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera): A. Szurpnicka, et al.; J. Ethnopharmacol. 298, 115604 (2022)
6. Telotristat ethyl reverses myxomatous changes in mice mitral valves: X. Wang, et al.; Front. Cardiovasc. Med. 9, 945672 (2022)
7. Airway basal stem cells generate distinct subpopulations of PNECs: H. Mou, et al.; Cell Rep. 35, 109011 (2021)
8. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression: J. Obermanns, et al.; Eur. J. Neurosci. 53, 3476 (2021), Application(s): ELISA using human serum
9. Neuroprotective role of camphor against ciprofloxacin induced depression in rats: modulation of Nrf-2 and TLR4: A. Salama, et al.; Immunopharmacol. Immunotoxicol. 43, 309 (2021)
10. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes: N. Nakatsuka, et al.; Mol. Psychiatry 26, 2753 (2021)
11. Serotonin involvement in okadaic acid-induced diarrhoea in vivo: M.C. Louzao, et al.; Arch. Toxicol. 95, 2797 (2021)
12. Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction: E. Vrigkou, et al.; Diagnostics (Basel) 10, 758 (2020)
13. Effects on tactile transmission by serotonin transporter inhibitors at Merkel discs of mouse whisker hair follicles: W. Chang & J.G. Gu; Mol. Pain 16, 1744806920938237 (2020)
14. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood: E. Mackey, et al.; PNAS 117, 23751 (2020), Application(s): Lysed BMMCs (bone marrow-derived Mast Cells) supernatants
15. Platelet inhibition by ticagrelor is protective against diabetic nephropathy in mice: M. Uil, et al.; FASEB J. 34, 13750 (2020), Application(s): Mouse plasma
16. Unexpected effects of long-term treatment with acetylsalicylic acid on late phase of pulmonary metastasis in murine model of orthotopic breast cancer: M. Smeda, et al.; PLoS One 15, e0230520 (2020)
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