靈敏可靠的ELISA試劑盒,用于檢測(cè)血漿、血清和尿液樣本中的緩激肽
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緩激肽(Bradykinin)于1949年被發(fā)現(xiàn),由血漿中的球蛋白前體在蛋白酶的作用下生成。它的名字表明它會(huì)促使腸道緩慢運(yùn)動(dòng)。早在1909年,人們就注意到在尿液中發(fā)現(xiàn)的物質(zhì)(后來(lái)被確定為激肽)具有降壓作用。激肽是血管舒張、血管通透性、NO 釋放和花生四烯酸動(dòng)員的效應(yīng)物。它們是血壓、腎功能和心臟功能的重要調(diào)節(jié)因子,并且還參與炎癥反應(yīng)。
緩激肽是通過血液中激肽釋放酶系統(tǒng)的作用(與凝血級(jí)聯(lián)有關(guān))從血球蛋白激肽原HK 產(chǎn)生的,但也可以在其他組織和器官中產(chǎn)生。除激肽釋放酶外,其他蛋白酶如纖溶酶也可釋放緩激肽。幾種肽酶可以降解激肽,包括血管緊張素轉(zhuǎn)化酶(ACE),這是一種可將血管緊張素 I 轉(zhuǎn)化為血管緊張素 II 并破壞緩激肽的金屬蛋白酶。血漿緩激肽迅速降解為較小的穩(wěn)定肽(BK1-5)形式。
Enzo Life Sciences的緩激肽(Bradykinin)ELISA試劑盒是一種競(jìng)爭(zhēng)比色法免疫檢測(cè)試劑盒,可在3小時(shí)內(nèi)得出結(jié)果。欣博盛生物作為Enzo Life Sciences授權(quán)中國(guó)一級(jí)代理,可提供該產(chǎn)品,歡迎咨詢。
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產(chǎn)品特點(diǎn)
◆ 靈敏、可靠地檢測(cè)低至 24.8 pg/ml 的緩激肽
◆ 僅需3小時(shí)即可得到多達(dá) 41 個(gè)樣本(帶復(fù)孔)的實(shí)驗(yàn)結(jié)果
◆ 動(dòng)態(tài)范圍寬,可輕松量化高表達(dá)水平和低表達(dá)水平的緩激肽
◆ 易于使用的液體顏色編碼試劑,可減少錯(cuò)誤
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產(chǎn)品信息
產(chǎn)品貨號(hào) | ADI-900-206 |
產(chǎn)品名稱 | Bradykinin ELISA kit(緩激肽ELISA試劑盒) |
規(guī)格 | 96 wells |
靈敏度 | 24.8 pg/ml |
檢測(cè)范圍 | 11.7-30,000 pg/ml |
應(yīng)用 | ELISA, Colorimetric detection |
檢測(cè)波長(zhǎng) | 450 nm |
適用樣本類型 | 血漿,血清和尿液樣本 |
適用種屬 | 不限種屬 |
交叉反應(yīng) | Bradykinin (100%) Lys-Bradykinin (Kallidin) (100%)? and Les-des-Arg9-Bradykinin (<1%), BK1-5 stable degradion product (<0.1%) |
使用/穩(wěn)定性 | Store all components at +4oC, except Standard at -20oC |
運(yùn)輸溫度 | Blue Ice |
短期保存溫度 | -20°C |
長(zhǎng)期保存溫度 | -20°C |
試劑盒組分 | Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash? Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP |
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標(biāo)準(zhǔn)曲線示例
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部分產(chǎn)品引用文獻(xiàn)
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19: C.P. Martens, et al.; EBioMedicine 83, 104195 (2022)
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats: J.S. Mishra & S. Kumar; Biol. Reprod. 2021, ioab051 (2021)
gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema: M. Fandaros, et al.; Inflammation 1007, 10753 (2021)
Plasma contact factors as novel biomarkers for diagnosing Alzheimer's disease: J. Park, et al.; Biomark. Res. 9, 5 (2021)
The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome: M. Punapart, et al.; Genes (Basel) 12, 1717 (2021)
An antibody against HK blocks Alzheimer's disease peptide β-amyloid-induced bradykinin release in human plasma: Z.L. Chen, et al.; PNAS 116, 22921 (2019)
Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2: Y. Zhou, et al.; Int. J. Oncol. 55, 131 (2019)
Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women: Pooja, et al.; Nitric Oxide 78, 103 (2018)
Protocols to assess coagulation following in vitro infection with hemorrhagic fever viruses: M.L. Tursiella, et al.; Methods Mol. Biol. 1604, 405 (2018)
Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protection: S. Kageyama, et al.; Liver Transpl. 21, 112 (2015)
Comparative effects of a novel angiotensin-converting enzyme inhibitor versus captopril on plasma angiotensins after myocardial infarction: J. Flores-Monroy, et al.; Pharmacology 94, 21 (2014)
High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis: A. Yang, et al.; J. Immunol. 192, 4398 (2014)
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