BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse VEGFR-2
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產(chǎn)品描述：
DC101-CP132單克隆抗體是原始DC101單克隆的重組嵌合型抗體?？勺兘Y(jié)構(gòu)域序列與原始DC101相同，但是恒定區(qū)序列已經(jīng)從大鼠IgG1變?yōu)樾∈驣gG2a。DC101-CP132單克隆抗體像原始大鼠IgG1抗體一樣，不包含F(xiàn)c突變。
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DC101-CP132單克隆抗體能與小鼠VEGFR-2(血管內(nèi)皮生長因子受體2)反應(yīng)，VEGFR-2也稱為CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成員。當(dāng)結(jié)合到其配體血管內(nèi)皮生長因子時(shí)發(fā)揮生理作用，血管內(nèi)皮生長因子受體-2在血管發(fā)育和通透性中起關(guān)鍵作用。血管內(nèi)皮生長因子受體-2在成人心臟、肺、腎、腦和骨骼肌的內(nèi)皮細(xì)胞中高表達(dá)，在其他組織中低表達(dá)。DC101單克隆抗體已被證明在體內(nèi)抑制VEGFR-2信號(hào)傳導(dǎo)。
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產(chǎn)品詳情：
產(chǎn)品名稱 | RecombiMAb anti-mouse VEGFR-2 |
產(chǎn)品貨號(hào) | CP132 |
產(chǎn)品規(guī)格 | 1/5/25/50/100mg |
反應(yīng)種屬 | Mouse |
克隆號(hào) | DC101-CP132 |
同種型 | Mouse IgG2a(switched from rat IgG1) |
免疫原 | Mouse VEGFR-2-SEAPs soluble receptor |
實(shí)驗(yàn)應(yīng)用 | in vivo?blocking of VEGF/VEGFR-2 signaling*
in vitro?blocking of VEGFR signaling*
Western blot*
*Reported for the original rat IgG1 DC101 antibody |
產(chǎn)品形式 | PBS, pH 7.0,Contains no stabilizers or preservatives |
純度 | >95%, Determined by SDS-PAGE |
聚合 | <5%, Determined by SEC |
無菌處理 | 0.2 μm filtration |
純化方式 | Protein G |
分子量 | 150 kDa |
小鼠病原檢測 | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
保存條件 | 抗體原液保存在4°C，不能冷凍保存。 |
推薦同型對照 | InVivoPlus mouse IgG2a isotype control, unknown specificity（貨號(hào)BP0085） |
推薦抗體稀釋液 | InVivoPure pH 7.0 Dilution Buffer（貨號(hào)IP0070） |
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該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：
應(yīng)用 | 文章 |
體內(nèi)VEGF/VEGFR-2信號(hào)阻斷 (in vivo blocking of VEGF/VEGFR-2 signaling) | 1.?Ding, X., et al. (2015). 'Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8' Cancer Res 75(2): 330-343. 2.?Lee, H. J., et al. (2015). 'Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature' Int J Radiat Oncol Biol Phys 91(3): 621-630. 3.?Arulanandam, R., et al. (2015). 'VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection' Cancer Cell 28(2): 210-224. 4.?Kizhatil, K., et al. (2014). 'Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process' PLoS Biol 12(7): e1001912. |
體內(nèi)VEGF/VEGFR-2信號(hào)阻斷，體外VEGFR信號(hào)阻斷 (in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling) | 1.Larrayoz, M., et al. (2014). 'Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype' EMBO Mol Med 6(4): 539-550. ? |
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